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Dietary tryptophan intervention counteracts stress-induced transcriptional changes in a teleost fish HPI axis during inflammation

2024-03-28Journal article Open access
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dc.contributor.authorPeixoto, Diogo
dc.contributor.authorCarvalho, Inês
dc.contributor.authorMachado, Marina
dc.contributor.authorAragão, Cláudia
dc.contributor.authorCostas, Benjamín
dc.contributor.authorAzeredo, Rita
dc.date.accessioned2024-09-12T10:26:51Z
dc.date.available2024-09-12T10:26:51Z
dc.date.issued2024-03-28
dc.description.abstractImmune nutrition is currently used to enhance fish health by incorporating functional ingredients into aquafeeds. This study aimed to investigate the connections between tryptophan nutrition and the network that regulates the communication pathways between neuroendocrine and immune systems in European seabass (Dicentrarchus labrax). When tryptophan was supplemented in the diet of unstressed fish, it induced changes in the hypothalamic-pituitary-interrenal axis response to stress. Tryptophan-mediated effects were observed in the expression of anti-inflammatory cytokines and glucocorticoid receptors. Tryptophan supplementation decreased pro-opiomelanocortin b-like levels, that are related with adrenocorticotropic hormone and cortisol secretion. When stressed fish fed a tryptophan-supplemented diet were subjected to an inflammatory stimulus, plasma cortisol levels decreased and the expression of genes involved in the neuroendocrine response was altered. Modulatory effects of tryptophan dietary intervention on molecular patterns seem to be mediated by altered patterns in serotonergic activity.eng
dc.description.sponsorship2021.04867.BD 2022.03304.CEECIND DL57/2016/ CP1361/ CT0033 2020.00290.CEECIND and 2022.03248.CEECIND
dc.identifier.doi10.1038/s41598-024-57761-0
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/25878
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science and Business Media
dc.relationUnraveling neuro-endocrine/immune modulatory roles of tryptophan during inflammation
dc.relationMethionine and tryptophan as nutraceutical strategies to improve mucosal immunity and vaccine efficiency in fish
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationThe modulatory role of tryptophan on the neuroendocrine and immune crosstalk
dc.relation.ispartofScientific Reports
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectStress response
dc.subjectFish physiology
dc.subjectMolecular immunology
dc.subjectNutritional immunology
dc.subjectImmune-neuroendocrine interaction
dc.titleDietary tryptophan intervention counteracts stress-induced transcriptional changes in a teleost fish HPI axis during inflammationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleUnraveling neuro-endocrine/immune modulatory roles of tryptophan during inflammation
oaire.awardTitleMethionine and tryptophan as nutraceutical strategies to improve mucosal immunity and vaccine efficiency in fish
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleThe modulatory role of tryptophan on the neuroendocrine and immune crosstalk
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FCVT-CVT%2F32349%2F2017/PT
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oaire.citation.issue1
oaire.citation.startPage7354
oaire.citation.titleScientific reports
oaire.citation.volume14
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAragão
person.givenNameCláudia
person.identifier174173
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person.identifier.ridK-2310-2012
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