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Hypocholesterolaemic pharmaceutical simvastatin disrupts reproduction and population growth of the amphipod Gammarus locusta at the ng/L range
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Orientador(es)
Resumo(s)
Simvastatin (SIM), a hypocholesterolaemic drug, is among the most widely used pharmaceuticals worldwide and is therefore of emerging environmental concern. Despite the ubiquitous nature of SIM in
the aquatic ecosystems, significant uncertainties exist about sublethal effects of the drug in aquatic
organisms. Therefore, here we aimed at investigating a multi-level biological response in the model
amphipod Gammarus locusta, following chronic exposures to low levels of SIM (64 ng/L to 8 mg/L). The
work integrated a battery of key endpoints at individual-level (survival, growth and reproduction) with
histopathological biomarkers in hepatopancreas and gonads. Additionally, an individual-based population modelling was used to project the ecological costs associated with long-term exposure to SIM at
the population level. SIM severely impacted growth, reproduction and gonad maturation of G. locusta,
concomitantly to changes at the histological level. Among all analysed endpoints, reproduction was
particularly sensitive to SIM with significant impact at 320 ng/L. These findings have important implications for environmental risk assessment and disclose new concerns about the effects of SIM in aquatic
ecosystems.
Descrição
Palavras-chave
Emerging pollutants Simvastatin Amphipods Chronic bioassays Multi-level responses
Contexto Educativo
Citação
Editora
Elsevier