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The use of enhanced green fluorescent protein to track matrix Gla protein expression during zebrafish (Danio rerio) development
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Resumo(s)
Matrix Gla protein (mgp), a vitamin K-dependent protein, is an important element of skeleton development as it regulates mineralization of both cartilaginous and bony structures, among others. Although mgp is found in a wide range of tissues, it is known to be expressed mostly by
chondrocytes and vascular smooth muscle cells. Accordingly, inhibition of Mgp function results in over-mineralization of cartilages and growth plates and in ectopic mineralizations, particularly in the vascular system. Besides being a well characterized protein and the existence
of developmental studies in zebrafish, there is still no description of monitoring mgp expression in live specimens.
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Citação
Cardeira da Silva J., Gavaia P.J., Brito A.B., Cancela M.L. 2008. The use of enhanced green fluorescent protein to track matrix Gla protein expression during zebrafish (Danio rerio) development. Marine Genomics Europe final meeting. CCMAR-University of Algarve May 13-16, Faro, Portugal.