Vanadate oligomers interactions with myosin

Aureliano, M.

http://hdl.handle.net/10400.1/4775

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Authors

Aureliano, M.

Abstract(s)

‘Monovanadate’containingamixtureofatleastfourdifferentvanadatespeciesand‘decavanadate’containingapparentlyonlytwovanadate species, mainly decameric species, inhibit myosin and actomyosin ATPase activities. The addition of myosin to ‘monovanadate’ and ‘decavanadate’solutionspromotesdifferentialincreasesonthe 51VNMRspectrallinewidthsofvanadateoligomers.Therelativeorderofline broadening upon myosin addition, reﬂecting the interaction of the vanadate oligomers with the protein, wasV10)V4)V1s1,whereas no changes were observed for monomeric vanadate species.It is concluded that decameric and tetrameric vanadate species interact quite potently with the protein and affect myosin as well actomyosin ATPase activities.

Keywords

Vanadate Myosin

URI

http://hdl.handle.net/10400.1/4775

Publisher

Elsevier

DOI

http://dx.doi.org/ 10.1016/S0162-0134(00)00021-0

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