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Occurrence of ghrelin-producing cells, the ghrelin receptor and Na+,K + -ATPase in tissues of Atlantic halibut (Hippoglossus hippoglossus) during early development

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dc.contributor.authorEinarsdóttir, Ingibjörg E.
dc.contributor.authorPower, Deborah
dc.contributor.authorJönsson, Elisabeth
dc.contributor.authorBjörnsson, Björn Thrandur
dc.date.accessioned2014-10-23T17:22:40Z
dc.date.available2014-10-23T17:22:40Z
dc.date.issued2011
dc.description.abstractGhrelin is a pituitary growth hormone (GH)- secretagogue that also has metabolic, reproductive, proliferative, immunological and brain functions in mammals. Far less is known about its role in fish. We have therefore performed an immunohistochemical determination of its tissue distribution in the developing Atlantic halibut (Hippoglossus hippoglossus) to gain insights into its potential function. Ghrelin immunoreactivity was detected in first-feeding halibut larvae in the skin, urinary bladder, gastrointestinal (GI) tract and olfactory lobe of the brain. In subsequent stages up to metamorphosis, ghrelin immunoreactivity declined in the skin and became evident in the gills. When the stomach developed, ghrelin immunoreactivity declined throughout the GI tract with the exception of the stomach, which exhibited an intense signal. Immunoreactive ghrelin cells were also present in the olfactory lobe, nerve and epithelium and in occasional cells of the buccal cavity and oesophagus. Ghrelin immunoreactivity had an overlapping distribution with that for Na+,K+-ATPase, colocalisation also being observed in some ionocytes of the gill. The coexpression of ghrelin and the GH-secretagogue receptor in the same tissue indicates that ghrelin can exert both endocrine and paracrine actions in the developing halibut. The presence of immunoreactive ghrelin in several osmoregulatory tissues, the GI tract and sensory tissue provides strong evidence that ghrelin has multiple functions during development and also suggests targets for future investigations.por
dc.description.sponsorshipThe authors thank Heiðdís Smáradóttir, Fiskey, Iceland, for the sampling and staging of the halibut larvae. This work was funded by the European Community projects “Arrested Development: The Molecular and Endocrine Basis of Flatfish Metamorphosis (ARRDE)” (FP6/Q5RS-2002-01192) and “Building a Biological Knowledge-Base on Fish Lifecycles for Competitive, Sustainable European Aaquaculture (LIFECYCLE)” (FP7/2007-2013 under grant agreement no. 222719).por
dc.identifier.citationIngibjörg Eir Einarsdóttir & Deborah M. Power & Elisabeth Jönsson & Björn Thrandur Björnsson, "Occurrence of ghrelin-producing cells, the ghrelin receptor and Na+,K + -ATPase in tissues of Atlantic halibut (Hippoglossus hippoglossus) during early development" in Cell Tissue Res (2011) 344:481–498 DOI 10.1007/s00441-011-1158-xpor
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-011-1158-x
dc.identifier.issn0302-766X
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5443
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringer Verlagpor
dc.relationBuilding a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs00441-011-1158-xpor
dc.subjectGhrelinpor
dc.subjectGastrointestinal tractpor
dc.subjectNa+,K+-ATPasepor
dc.subjectOntogenypor
dc.subjectAtlantic halibutpor
dc.subjectHippoglossus hippoglossus (Teleostei)por
dc.titleOccurrence of ghrelin-producing cells, the ghrelin receptor and Na+,K + -ATPase in tissues of Atlantic halibut (Hippoglossus hippoglossus) during early developmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBuilding a biological knowledge-base on fish lifecycles for competitive, sustainable European aquaculture
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/222719/EU
oaire.citation.endPage498por
oaire.citation.issue3
oaire.citation.startPage481por
oaire.citation.titleCell and Tissue Researchpor
oaire.citation.volume344por
oaire.fundingStreamFP7
person.familyNamePower
person.givenNameDeborah Mary
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isProjectOfPublicationeb95e695-02d8-41f1-88df-951429f0f4f3
relation.isProjectOfPublication.latestForDiscoveryeb95e695-02d8-41f1-88df-951429f0f4f3

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