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Publication
Occurrence of ghrelin-producing cells, the ghrelin receptor and Na+,K + -ATPase in tissues of Atlantic halibut (Hippoglossus hippoglossus) during early development
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Advisor(s)
Abstract(s)
Ghrelin is a pituitary growth hormone (GH)-
secretagogue that also has metabolic, reproductive, proliferative,
immunological and brain functions in mammals.
Far less is known about its role in fish. We have therefore
performed an immunohistochemical determination of its
tissue distribution in the developing Atlantic halibut
(Hippoglossus hippoglossus) to gain insights into its
potential function. Ghrelin immunoreactivity was detected
in first-feeding halibut larvae in the skin, urinary bladder,
gastrointestinal (GI) tract and olfactory lobe of the brain. In
subsequent stages up to metamorphosis, ghrelin immunoreactivity
declined in the skin and became evident in the gills.
When the stomach developed, ghrelin immunoreactivity
declined throughout the GI tract with the exception of the
stomach, which exhibited an intense signal. Immunoreactive
ghrelin cells were also present in the olfactory lobe, nerve and
epithelium and in occasional cells of the buccal cavity and oesophagus. Ghrelin immunoreactivity had an overlapping
distribution with that for Na+,K+-ATPase, colocalisation also
being observed in some ionocytes of the gill. The coexpression
of ghrelin and the GH-secretagogue receptor in
the same tissue indicates that ghrelin can exert both endocrine
and paracrine actions in the developing halibut. The presence
of immunoreactive ghrelin in several osmoregulatory tissues,
the GI tract and sensory tissue provides strong evidence that
ghrelin has multiple functions during development and also
suggests targets for future investigations.
Description
Keywords
Ghrelin Gastrointestinal tract Na+,K+-ATPase Ontogeny Atlantic halibut Hippoglossus hippoglossus (Teleostei)
Pedagogical Context
Citation
Ingibjörg Eir Einarsdóttir & Deborah M. Power & Elisabeth Jönsson & Björn Thrandur Björnsson, "Occurrence of ghrelin-producing cells, the ghrelin receptor and Na+,K + -ATPase in tissues of Atlantic halibut (Hippoglossus hippoglossus) during early development" in Cell Tissue Res (2011) 344:481–498 DOI 10.1007/s00441-011-1158-x
Publisher
Springer Verlag