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Phytochemicals and bioactivities of the halophyte sea mayweed (Tripleurospermum maritimum L.)

2025-10-30Journal article Open access
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dc.contributor.authorLemoine, Clément
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorDauvergne, Xavier
dc.contributor.authorCérantola, Stéphane
dc.contributor.authorCustódio, Luísa
dc.contributor.authorMagné, Christian
dc.date.accessioned2025-12-22T09:49:58Z
dc.date.available2025-12-22T09:49:58Z
dc.date.issued2025-10-30
dc.description.abstractSea mayweed (Tripleurospermum maritimum L. syn. Matricaria maritima) is a halophytic species widely distributed along the Atlantic shoreline. Unlike other Tripleurospermum species, the chemical composition and biological activities of this halophyte have received no attention. Here, a hydroalcoholic extract of sea mayweed leaves was evaluated for in vitro antioxidant (DPPH, ABTS, and FRAP bioassays), anti-inflammatory (NO reduction in RAW 264.7 macrophages), anti-diabetic (alpha-glucosidase inhibition), neuroprotective (inhibition of acetylcholinesterase), and skin protective (tyrosinase, melanogenesis, elastase, and collagenase inhibition) activities. Solid–liquid partition chromatography of the extract and NMR characterization of its fractions allowed the identification of some major compounds, including fructo-oligosaccharides in the MeOH20% fraction, a new carbohydrate called tripleurospermine (1), 3-5-dicaffeoylquinic acid (2) in the MeOH40% fraction, and matricaria lactone (3) in the MeOH80% fraction. MeOH40 fraction exhibited strong antioxidant, anti-tyrosinase (thus skin-whitening potential), and anti-glycosidase activities (anti-diabetic potential), whereas MeOH80% fraction showed anti-inflammatory and anti-diabetic potential. Overall, our results suggest that sea mayweed may have dietary or medicinal uses due to its biochemical composition and bioactivities.eng
dc.description.sponsorshipCCMAR/Multi/04326/2019; CEECIND/00425/2017
dc.identifier.doi10.3390/md23110420
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/27997
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofMarine Drugs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntidiabetic
dc.subjectAnti-inflammatory
dc.subjectAntioxidant
dc.subjectBio-guiding
dc.subjectNMR characterization
dc.subjectTripleurospermum maritimum
dc.subjectWhitening activity
dc.titlePhytochemicals and bioactivities of the halophyte sea mayweed (Tripleurospermum maritimum L.)eng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.startPage420
oaire.citation.titleMarine Drugs
oaire.citation.volume23
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameCustódio
person.givenNameMaria João
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c

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