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Further evidence of possible therapeutic uses of Sambucus nigra L. extracts by the assessment of the In Vitro and In Vivo anti-inflammatory properties of Its PLGA and PCL-Based Nanoformulations

2020-12-04Journal article Open Access
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dc.contributor.authorMota, Ana Henriques
dc.contributor.authorDuarte, Noélia
dc.contributor.authorSerra, Ana Teresa
dc.contributor.authorFerreira, António
dc.contributor.authorBronze, Maria Rosário
dc.contributor.authorCustódio, Luísa
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorSimões, Sandra
dc.contributor.authorRijo, Patrícia
dc.contributor.authorAscensão, Lia
dc.contributor.authorFaísca, Pedro
dc.contributor.authorViana, Ana Silveira
dc.contributor.authorPinto, Rui
dc.contributor.authorKumar, Pradeep
dc.contributor.authorAlmeida, António José
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2021-01-14T12:02:06Z
dc.date.available2021-01-14T12:02:06Z
dc.date.issued2020-12-04
dc.date.updated2021-01-08T14:44:30Z
dc.description.abstract<i>Sambucus nigra</i> L. is widely used in traditional medicine with different applications. However, confirmative studies are strongly required. This study aimed to assess the biological activities of the <i>S. nigra</i> flower’s extract encapsulated into two different types of nanoparticles for optimizing its properties and producing further evidence of its potential therapeutic uses. Different nanoparticles (poly(lactide-co-glycolide, PLGA) and poly-Ɛ-caprolactone (PCL), both with oleic acid, were prepared by emulsification/solvent diffusion and solvent-displacement methods, respectively. Oleic acid was used as a capping agent. After the nanoparticles’ preparation, they were characterized and the biological activities were studied in terms of collagenase, in vitro and in vivo anti-inflammatory, and in vitro cell viability. Rutin and naringenin were found to be the major phenolic compounds in the studied extract. The encapsulation efficiency was higher than 76% and revealed to have an impact on the release of the extract, mainly for the PLGA. Moreover, biochemical and histopathological analyses confirmed that the extract-loaded PLGA-based nanoparticles displayed the highest anti-inflammatory activity. In addition to supporting the previously reported evidence of potential therapeutic uses of <i>S. nigra</i>, these results could draw the pharmaceutical industry’s interest to the novelty of the nanoproducts.pt_PT
dc.description.sponsorshipAuthors also gratefully acknowledge the Régiefrutas and Fundação para a Ciência e a Tecnologia (FCT) (UIDB/04138/2020, UIDB/00100/2020, UIDP/50017/2020+UIDB/50017/2020) and Portugal 2020 to the Portuguese Mass Spectrometry Network (LISBOA-01-0145-FEDER-402-022125) for financial support. Furthermore, the authors are also grateful to the work supported by the FCT and the Portuguese National and Regional Budget, through CCMAR/Multi/04326/2019 project. Finally, Luísa Custódio was supported by the FCT Scientific Employment Stimulus (CEECIND/00425/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/pharmaceutics12121181
dc.identifier.citationPharmaceutics 12 (12): 1181 (2020)pt_PT
dc.identifier.doi10.3390/pharmaceutics12121181pt_PT
dc.identifier.issndoi: 10.3390/pharmaceutics12121181
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.1/14961
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationResearch Institute for Medicines
dc.relationCentro de Química Estrutural
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSambucus nigra Lpt_PT
dc.subjectNanoparticlespt_PT
dc.subjectAnti-inflammatory activitypt_PT
dc.subjectCollagenase inhibitionpt_PT
dc.subjectSafety assessmentpt_PT
dc.titleFurther evidence of possible therapeutic uses of Sambucus nigra L. extracts by the assessment of the In Vitro and In Vivo anti-inflammatory properties of Its PLGA and PCL-Based Nanoformulationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1181pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCustódio
person.givenNameLuísa
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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