Cellular interactions in the tumor microenvironment: the role of secretome

da Cunha, Bianca Rodrigues; Domingos, Célia; Stefanini, Ana Carolina Buzzo; Henrique, Tiago; Polachini, Giovana Mussi; Castelo-Branco, Pedro; Tajara, Eloiza Helena

http://hdl.handle.net/10400.1/12812

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Authors

da Cunha, Bianca Rodrigues

Domingos, Célia

Stefanini, Ana Carolina Buzzo

Henrique, Tiago

Polachini, Giovana Mussi

Castelo-Branco, Pedro

Tajara, Eloiza Helena

Abstract(s)

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses.