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Cellular interactions in the tumor microenvironment: the role of secretome

2019Journal article Open access
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dc.contributor.authorda Cunha, Bianca Rodrigues
dc.contributor.authorDomingos, Célia
dc.contributor.authorStefanini, Ana Carolina Buzzo
dc.contributor.authorHenrique, Tiago
dc.contributor.authorPolachini, Giovana Mussi
dc.contributor.authorCastelo-Branco, Pedro
dc.contributor.authorTajara, Eloiza Helena
dc.date.accessioned2019-10-10T15:29:59Z
dc.date.available2019-10-10T15:29:59Z
dc.date.issued2019
dc.description.abstractOver the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses.pt_PT
dc.description.sponsorshipAgência financiadora Fundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) FAPESP 10/51168-0 12/06048-2 13/03839-1 National Council for Scientific and Technological Development (CNPq) CNPq 306216/2010-8 Fundacao para a Ciencia e a Tecnologia (FCT) UID/BIM/04773/2013 CBMR 1334pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.7150/jca.21780
dc.identifier.issn1837-9664
dc.identifier.urihttp://hdl.handle.net/10400.1/12812
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIvyspring International Publisherpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectMicroenvironmentpt_PT
dc.subjectSecretomept_PT
dc.titleCellular interactions in the tumor microenvironment: the role of secretomept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.endPage4587pt_PT
oaire.citation.issue19pt_PT
oaire.citation.startPage4574pt_PT
oaire.citation.titleJournal of Cancerpt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream5876
person.familyNameDomingos
person.familyNameCastelo-Branco
person.givenNameCélia
person.givenNamePedro
person.identifier.ciencia-idC410-E105-17DF
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.orcid0000-0002-8828-1366
person.identifier.orcid0000-0002-3453-3978
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationbb25b5ad-1769-42be-a7d3-8fe76215aa23
relation.isAuthorOfPublication.latestForDiscoverybb25b5ad-1769-42be-a7d3-8fe76215aa23
relation.isProjectOfPublicatione13142f2-37b8-4b5a-b2cd-352e62003184
relation.isProjectOfPublication.latestForDiscoverye13142f2-37b8-4b5a-b2cd-352e62003184

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