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Effect of saffron supplementation on liver enzymes: a systematic review and meta-analysis of randomized controlled trials

dc.contributor.authorHasani, Motahareh
dc.contributor.authorMalekahmadi, Mahsa
dc.contributor.authorRezamand, Gholamreza
dc.contributor.authorEstêvão, M. Dulce
dc.contributor.authorPizarro, Ana Beatriz
dc.contributor.authorHeydari, Hafez
dc.contributor.authorHoong, Wong Chun
dc.contributor.authorArafah, Omar Ahnaf
dc.contributor.authorBarakeh, Abdul Rahman Riad
dc.contributor.authorRahman, Areej
dc.contributor.authorAlrashidi, Mona Saud K.
dc.contributor.authorAbu-Zaid, Ahmed
dc.date.accessioned2022-02-24T11:06:02Z
dc.date.available2022-02-24T11:06:02Z
dc.date.issued2021
dc.description.abstractBackground and aims: Possible protective effects of saffron (Crocus sativus L) have been reported in several randomized clinical trials (RCTs). Current systematic review was performed to summarize the efficacy of saffron intake on liver enzymes. Methods: An electronic database search was conducted on PubMed/Medline, Scopus, Web of Science, and Cochrane for RCTs comparing effect of saffron and placebo on liver enzymes from inception to July 2021. There was no restriction in language of included studies and we calculated the standardized mean difference (SMD) and 95% Confidence Intervals (CI) for each variable. Random-effect model was used to calculate effect size. Results: Eight studies (n = 463 participants) were included in the systematic review. The saffron intake was associated with a statistically significant decrease in aspartate aminotransferase (AST) (SMD: -0.18; 95% CI: -0.34, -0.02; I-2 = 0%) in comparison to placebo intake. Our results also indicated that saffron consumption did not have a significant effect on alanine aminotransferase (ALT) (SMD: -0.14; 95% CI: -0.36, 0.09; I-2 = 47.0%) and alkaline phosphatase (ALP) levels (SMD: 0.14; 95% CI: -0.18, 0.46; I-2 = 42.9%) compared to placebo. Conclusions: Saffron intake showed beneficial impacts on circulating AST levels. However, larger well-designed RCTs are still needed to clarify the effect of saffron intake on these and other liver enzymes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.dsx.2021.102311pt_PT
dc.identifier.issn1871-4021
dc.identifier.urihttp://hdl.handle.net/10400.1/17602
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectSaffronpt_PT
dc.subjectCrocuspt_PT
dc.subjectAlanine aminotransferasept_PT
dc.subjectAspartate aminotransferasept_PT
dc.subjectAlkaline phosphatasept_PT
dc.titleEffect of saffron supplementation on liver enzymes: a systematic review and meta-analysis of randomized controlled trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage102311pt_PT
oaire.citation.titleDiabetes & Metabolic Syndrome: Clinical Research & Reviewspt_PT
oaire.citation.volume15pt_PT
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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