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A brief overview of the oral delivery of insulin as an alternative to the parenteral delivery

2020Journal article Restricted access
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dc.contributor.authorMacedo, Ana
dc.contributor.authorFilipe, Patricia
dc.contributor.authorThome, Natalia G.
dc.contributor.authorVieira, Joao
dc.contributor.authorOliveira, Carolina
dc.contributor.authorTeodosio, Catarina
dc.contributor.authorFerreira, Raquel
dc.contributor.authorRoque, Luis
dc.contributor.authorFonte, Pedro
dc.date.accessioned2021-06-24T11:36:09Z
dc.date.available2021-06-24T11:36:09Z
dc.date.issued2020
dc.description.abstractDiabetes mellitus greatly affects the quality of life of patients and has a worldwide prevalence. Insulin is the most commonly used drug to treat diabetic patients and is usually administered through the subcutaneous route. However, this route of administration is ineffective due to the low concentration of insulin at the site of action. This route of administration causes discomfort to the patient and increases the risk of infection due to skin barrier disturbance caused by the needle. The oral administration of insulin has been proposed to surpass the disadvantages of subcutaneous administration. In this review, we give an overview of the strategies to deliver insulin by the oral route, from insulin conjugation to encapsulation into nanoparticles. These strategies are still under development to attain efficacy and effectiveness that are expected to be achieved in the near future.
dc.description.sponsorshipFEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 Operational Programme for Competitiveness and Internationalization (POCI)
dc.description.sponsorshipPortuguese funds through FCT - Fundacao para a Ciencia e a Tecnologia [POCI-01-0145-FEDER032610 -PTDC/MECDER/32610/2017]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.2174/1566524019666191010095522
dc.identifier.issn1566-5240
dc.identifier.urihttp://hdl.handle.net/10400.1/16646
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBentham Science Publishers
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subjectDiabetes mellitus
dc.subjectInsulin
dc.subjectOral delivery
dc.subjectNanoparticle
dc.subjectAbsorption enhancer
dc.subjectEnzyme inhibitor
dc.subjectIntestinal patch
dc.titleA brief overview of the oral delivery of insulin as an alternative to the parenteral delivery
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage143
oaire.citation.issue2
oaire.citation.startPage134
oaire.citation.titleCurrent Molecular Medicine
oaire.citation.volume20
person.familyNameFonte
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationa5a5c2b2-9112-4bf4-8618-8c2051bbc116
relation.isAuthorOfPublication.latestForDiscoverya5a5c2b2-9112-4bf4-8618-8c2051bbc116

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