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Toll-like receptor evolution: does temperature matter?

2022-02Journal article Open access
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dc.contributor.authorSousa, Carmen
dc.contributor.authorFernandes, Stefan A.
dc.contributor.authorCardoso, João
dc.contributor.authorWang, Ying
dc.contributor.authorZhai, Wanying
dc.contributor.authorGuerreiro, Pedro
dc.contributor.authorChen, Liangbiao
dc.contributor.authorCanario, A.V.M.
dc.contributor.authorPower, Deborah
dc.date.accessioned2023-03-18T10:09:56Z
dc.date.available2023-03-18T10:09:56Z
dc.date.issued2022-02
dc.description.abstractToll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation into Tlr evolution. Gene homologues of tlr members in teleosts from temperate regions were present in the genome of Antarctic Nototheniidae and the non-Antarctic sister lineage Bovichtidae. Overall, in Nototheniidae apart from D. mawsoni, no major tlr gene family expansion or contraction occurred. Instead, lineage and species-specific changes in the ectodomain and LRR of Tlrs occurred, particularly in the Tlr11 superfamily that is well represented in fish. Positive selective pressure and associated sequence modifications in the TLR ectodomain and within the leucine-rich repeats (LRR), important for pathogen recognition, occurred in Tlr5, Tlr8, Tlr13, Tlr21, Tlr22, and Tlr23 presumably associated with the unique Antarctic microbiota. Exposure to lipopolysaccharide (Escherichia coli O111:B4) Gram negative bacteria did not modify tlr gene expression in N. rossii head-kidney or anterior intestine, although increased water temperature (+4 degrees C) had a significant effect.pt_PT
dc.description.sponsorshipPTDC/BIAANM/3484/2014; 41761134050; FCT-NSFC/0002/2016; FACC PROPOLAR (2016/2017);pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fimmu.2022.812890pt_PT
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10400.1/19273
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relationEvolution of the immune system in Antarctic notothenioids
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTLRpt_PT
dc.subjectAntarctic fishpt_PT
dc.subjectInnate immunitypt_PT
dc.subjectImmune challengept_PT
dc.subjectCold temperaturept_PT
dc.subjectEvolutionpt_PT
dc.titleToll-like receptor evolution: does temperature matter?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleEvolution of the immune system in Antarctic notothenioids
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F120040%2F2016/PT
oaire.citation.titleFrontiers in Immunologypt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVieira de Sousa
person.familyNameCardoso
person.familyNameGuerreiro da Costa Guerreiro
person.familyNameCanario
person.familyNamePower
person.givenNameCármen Sofia
person.givenNameJoão
person.givenNamePedro Miguel
person.givenNameAdelino
person.givenNameDeborah Mary
person.identifier14332
person.identifierA-2539-2009
person.identifier143624
person.identifier.ciencia-idE511-2F93-F25D
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id5C13-965D-3148
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-3483-1932
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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