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Cloning, tissue and ontogenetic expression of the taurine transporter in the flatfish Senegalese sole (Solea senegalensis)

2012Journal article Open access
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dc.contributor.authorPinto, W.
dc.contributor.authorRønnestad, I.
dc.contributor.authorJordal, A. E. O.
dc.contributor.authorDinis, Maria Teresa
dc.contributor.authorAragão, C.
dc.date.accessioned2014-07-02T12:51:00Z
dc.date.available2014-07-02T12:51:00Z
dc.date.issued2012
dc.date.updated2014-06-27T15:30:56Z
dc.descriptionTexto integral disponível através do editorpor
dc.description.abstractFlatfish species seem to require dietary taurine for normal growth and development. Although dietary taurine supplementation has been recommended for flatfish, little is known about the mechanisms of taurine absorption in the digestive tract of flatfish throughout ontogeny. This study described the cloning and ontogenetic expression of the taurine transporter (TauT) in the flatfish Senegalese sole (Solea senegalensis). Results showed a high similarity between TauT in Senegalese sole and other vertebrates, but a change in TauT amino acid sequences indicates that taurine transport may differ between mammals and fish, reptiles or birds. Moreover, results showed that Senegalese sole metamorphosis is an important developmental trigger to promote taurine transport in larvae, especially in muscle tissues, which may be important for larval growth. Results also indicated that the capacity to uptake dietary taurine in the digestive tract is already established in larvae at the onset of metamorphosis. In Senegalese sole juveniles, TauT expression was highest in brain, heart and eye. These are organs where taurine is usually found in high concentrations and is believed to play important biological roles. In the digestive tract of juveniles, TauT was more expressed in stomach and hindgut, indicating that dietary taurine is quickly absorbed when digestion begins and taurine endogenously used for bile salt conjugation may be recycled at the posterior end of the digestive tract. Therefore, these results suggest an enterohepatic recycling pathway for taurine in Senegalese sole, a process that may be important for maintenance of the taurine body levels in flatfish species.por
dc.identifier.citationPinto, W.; Rønnestad, I.; Jordal, A.-E.O.; Gomes, A.S.; Dinis, M.T.; Aragão, C.Cloning, tissue and ontogenetic expression of the taurine transporter in the flatfish Senegalese sole (Solea senegalensis), Amino Acids, 42, 4, 1317-1327, 2012.por
dc.identifier.doihttp://dx.doi.org/ 10.1007/s00726-010-0826-6
dc.identifier.issn0939-4451
dc.identifier.urihttp://hdl.handle.net/10400.1/4616
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs00726-010-0826-6por
dc.subjectTaurine transporterpor
dc.subjectTauTpor
dc.subjectSLC6A6por
dc.subjectSenegalese solepor
dc.subjectFlatfishpor
dc.subjectOntogenypor
dc.titleCloning, tissue and ontogenetic expression of the taurine transporter in the flatfish Senegalese sole (Solea senegalensis)por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1327por
oaire.citation.issue4por
oaire.citation.startPage1317por
oaire.citation.titleAmino Acidspor
oaire.citation.volume42por
person.familyNameDinis
person.familyNameAragão
person.givenNameMaria Teresa
person.givenNameCláudia
person.identifier174173
person.identifier.ciencia-id5414-4ACF-BF90
person.identifier.ciencia-idD01E-0726-9F3E
person.identifier.orcid0000-0001-7813-1324
person.identifier.orcid0000-0002-9217-0183
person.identifier.ridK-2310-2012
person.identifier.scopus-author-id7004150905
person.identifier.scopus-author-id55903315700
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication309dec19-8aa9-4bea-8665-42dd4b3a9894
relation.isAuthorOfPublicationbc649967-3b39-41dc-8fab-b60c24e65286
relation.isAuthorOfPublication.latestForDiscoverybc649967-3b39-41dc-8fab-b60c24e65286

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