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Impact of biohybrid magnetite nanoparticles and moroccan propolis on adherence of methicillin resistant strains of staphylococcus aureus

2016Journal article Open access
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dc.contributor.authorEL-GEUNDOUZ, Soukaina
dc.contributor.authorAAZZA, Smail
dc.contributor.authorLyoussi, Badiaa
dc.contributor.authorBankova, Vassya
dc.contributor.authorLourenço, J. P.
dc.contributor.authorCosta, Ana
dc.contributor.authorMariano, José
dc.contributor.authorMiguel, Maria
dc.contributor.authorFaleiro, Maria Leonor
dc.date.accessioned2017-01-05T11:22:11Z
dc.date.available2017-01-05T11:22:11Z
dc.date.issued2016
dc.description.abstractBiofilm bacteria are more resistant to antibiotics than planktonic cells. Propolis possesses antimicrobial activity. Generally, nanoparticles containing heavy metals possess antimicrobial and antibiofilm properties. In this study, the ability of adherence of Methicillin Resistant Strains of Staphylococcus aureus (MRSA) to catheters treated with magnetite nanoparticles (MNPs), produced by three methods and functionalized with oleic acid and a hydro-alcoholic extract of propolis from Morocco, was evaluated. The chemical composition of propolis was established by gas chromatography mass spectrometry (GC-MS), and the fabricated nanostructures characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Mossbauer spectroscopy and Fourrier transform infrared spectroscopy (FTIR). The capacity for impairing biofilm formation was dependent on the strain, as well as on the mode of production of MNPs. The co-precipitation method of MNPs fabrication using Fe(3+) and Na₂SO₃ solution and functionalized with oleic acid and propolis was the most effective in the impairment of adherence of all MRSA strains to catheters (p < 0.001). The adherence of the strain MRSA16 was also significantly lower (p < 0.001) when the catheters were treated with the hybrid MNPs with oleic acid produced by a hydrothermal method. The anti-MRSA observed can be attributed to the presence of benzyl caffeate, pinocembrin, galangin, and isocupressic acid in propolis extract, along with MNPs. However, for MRSA16, the impairment of its adherence on catheters may only be attributed to the hybrid MNPs with oleic acid, since very small amount, if any at all of propolis compounds were added to the MNPs.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttp://dx.doi.org/10.3390/molecules21091208pt_PT
dc.identifier.issn1420-3049
dc.identifier.otherAUT: JLO01215;
dc.identifier.urihttp://hdl.handle.net/10400.1/8917
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationStrategic Project - UI 4023 - 2011-2012
dc.subjectCo-precipitationpt_PT
dc.subjectHydrothermalpt_PT
dc.subjectFunctionalizationpt_PT
dc.subjectPropolispt_PT
dc.subjectFlavonoidspt_PT
dc.subjectDiterpenespt_PT
dc.titleImpact of biohybrid magnetite nanoparticles and moroccan propolis on adherence of methicillin resistant strains of staphylococcus aureuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 4023 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI4023%2F2011/PT
oaire.citation.endPage1226pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1208pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume21pt_PT
oaire.fundingStream5876
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
person.familyNameEl-Guendouz
person.familyNameAAZZA
person.familyNameLourenço
person.familyNameMariano
person.familyNameMiguel
person.familyNameFaleiro
person.givenNameSoukaina
person.givenNameSmail
person.givenNameJoão P.
person.givenNameJosé
person.givenNameMaria da Graça
person.givenNameMaria Leonor
person.identifierhttps://scholar.google.com/citations?user=CYBI8q8AAAAJ&hl=fr
person.identifier1426445
person.identifier634248
person.identifier252666
person.identifier.ciencia-id3E11-53A1-4D90
person.identifier.ciencia-idE416-77DF-6A97
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person.identifier.ciencia-idDE19-7D9D-00D0
person.identifier.ciencia-id6110-6FE7-DF28
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.orcid0000-0002-3341-9452
person.identifier.orcid0000-0002-9339-8999
person.identifier.orcid0000-0002-0501-6672
person.identifier.orcid0000-0002-8480-617X
person.identifier.orcid0000-0003-2507-4228
person.identifier.orcid0000-0002-3878-6948
person.identifier.ridL-7630-2017
person.identifier.ridA-7758-2008
person.identifier.ridO-5252-2018
person.identifier.scopus-author-id57190122389
person.identifier.scopus-author-id51664684500
person.identifier.scopus-author-id57195730600
person.identifier.scopus-author-id12647832000
person.identifier.scopus-author-id35562054500
person.identifier.scopus-author-id6507927018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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