The growth curve method to rapidly derive the antibacterial potential of polyoxovanadates

Marques-da-Silva, Dorinda; Mal, Sib Sankar; Aureliano, Manuel; Lagoa, Ricardo

http://hdl.handle.net/10400.1/28259

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Autores

Marques-da-Silva, Dorinda

Mal, Sib Sankar

Aureliano, Manuel

Lagoa, Ricardo

Resumo(s)

In previous studies (Marques-da-Silva et al., 2019), we measured the minimum inhibitory concentrations (MICs) of three polyoxovanadates, namely V10, MnV11, and MnV13, against Escherichia coli. MICs were obtained following the standard method, which requires a 16–20 h culture and might neglect the effects of the compounds’ metabolism during incubation. In this work, we studied the action of those compounds against Enterococcus faecalis by monitoring the bacterial growth kinetics, and we observed that the inhibition was evident from the beginning of the exponential phase. Notably, data collected from just a 7 h culture was enough to identify the compounds with stronger antibacterial activity according to standard MICs.