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FOXO transcription factors as therapeutic targets in human diseases

2022Journal article Restricted
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dc.contributor.authorOrea-Soufi, Alba
dc.contributor.authorPaik, Jihye
dc.contributor.authorBragança, José
dc.contributor.authorDonlon, Timothy A.
dc.contributor.authorWillcox, Bradley J.
dc.contributor.authorLink, Wolfgang
dc.date.accessioned2023-02-11T10:25:30Z
dc.date.available2023-02-11T10:25:30Z
dc.date.issued2022
dc.description.abstractForkhead box (FOX)O proteins are transcription factors (TFs) with four members in mammals designated FOXO1, FOXO3, FOXO4, and FOXO6. FOXO TFs play a pivotal role in the cellular adaptation to diverse stress conditions. FOXO proteins act as context-dependent tumor suppressors and their dysregulation has been implicated in several age-related diseases. FOXO3 has been established as a major gene for human longevity. Accordingly, FOXO proteins have emerged as potential targets for the therapeutic development of drugs and geroprotectors. In this review, we provide an overview of the most recent advances in our under-standing of FOXO regulation and function in various pathological conditions. We discuss strategies targeting FOXOs directly or by the modulation of upstream regulators, shedding light on the most promising intervention points. We also reveal the most relevant clinical indications and discuss the potential, trends, and challenges of modulating FOXO activity for therapeutic purposes.pt_PT
dc.description.sponsorshipALG-01-0145-FEDER-28044
dc.description.sponsorship072586
dc.description.sponsorshipALG-01-0145-FEDER-072586
dc.description.sponsorshipEuropean Cooperation in Science and Technology (COST) CA17104
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.tips.2022.09.010pt_PT
dc.identifier.issn0165-6147
dc.identifier.urihttp://hdl.handle.net/10400.1/19056
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationVariant sequences Identification in human genomes and Their Assignment as true causative mutations for LVNC - VITAL
dc.subjectFOXO transcription factorspt_PT
dc.subjectDrugs and geroprotectorspt_PT
dc.subjectCancerpt_PT
dc.subjectCardiovascular and neurodegenerative diseasespt_PT
dc.subjectDiabetespt_PT
dc.titleFOXO transcription factors as therapeutic targets in human diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVariant sequences Identification in human genomes and Their Assignment as true causative mutations for LVNC - VITAL
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTM-TEC%2F28044%2F2017/PT
oaire.citation.endPage1084pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1070pt_PT
oaire.citation.titleTrends in Pharmacological Sciencespt_PT
oaire.citation.volume43pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameOrea-Soufi
person.familyNameBragança
person.givenNameAlba
person.givenNameJosé
person.identifier.ciencia-id6C16-45B1-8301
person.identifier.ciencia-idAC1D-FA9D-F66F
person.identifier.orcid0000-0001-9264-6519
person.identifier.orcid0000-0001-9566-400X
person.identifier.scopus-author-id56964305800
person.identifier.scopus-author-id6602220001
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication869c0839-5336-453f-b5a6-3c19e0c02ed5
relation.isAuthorOfPublication27334e02-e955-4939-b9b5-bdee5b5f9328
relation.isAuthorOfPublication.latestForDiscovery27334e02-e955-4939-b9b5-bdee5b5f9328
relation.isProjectOfPublicationb05c55aa-af8f-480b-ab0f-a3c27336c897
relation.isProjectOfPublication.latestForDiscoveryb05c55aa-af8f-480b-ab0f-a3c27336c897

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