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Gonadal steroidogenesis in response to estradiol-17ß administration in the sea bream (Sparus aurata L.)

2001Journal article Restricted access
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dc.contributor.authorCondeça, João B.
dc.contributor.authorCanario, Adelino V. M.
dc.date.accessioned2014-05-14T09:19:22Z
dc.date.available2014-05-14T09:19:22Z
dc.date.issued2001
dc.date.updated2014-05-09T10:02:58Z
dc.description.abstractThe sea bream (Sparus aurata) is a protandrous hermaphrodite teleost fish in which estrogen administration induces testicular regression without influencing ovarian development. To analyze the changes in steroidogenesis of fish treated with two levels of estrogen (2 and 10 mg z kg21) and untreated control fish, fragments of gonads were incubated with tritiated 17-hydroxyprogesterone and the metabolites identified. The ability to extract radioactivity decreased with incubation time and was lower in gonads containing a larger proportion of ovarian tissue. The difference in steroidogenic capacity between control and estrogen-treated groups was generally quantitative rather than qualitative and paralleled the observed histological changes. The same metabolites were identified in all three groups, but estrogen treatment caused a marked inhibition of 5b-reduction, 3a-reduction, side-chain cleavage, and 11b-hydroxylation. The main androgens identified were 11b-hydroxy-4-androstene-3,17-dione and 3a-hydroxy-5b-androstane-3,17-dione, and the synthesis of both steroids was inhibited by estrogen treatment. Of the more polar pregnanes, 5bpregnane-3a,17,20a-triol and 5b-pregnane-3a,17,20btriol were detected in significant amounts, but only the latter appeared to be associated with development of the testis (in the untreated fish). A feature of sea bream gonadal steroidogenesis less common in other teleosts was the presence of 6a- and 6b-hydroxylation.por
dc.identifier.citationCondeça, João B.; Canario, Adelino V.M. Gonadal Steroidogenesis in Response to Estradiol-17ß Administration in the Sea Bream (Sparus aurata L.), General and Comparative Endocrinology, 124, 1, 82-96, 2001.por
dc.identifier.doihttp://dx.doi.org/10.1006/gcen.2001.7689
dc.identifier.issn0016-6480
dc.identifier.otherAUT: ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3920
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAcademic Presspor
dc.subjectSteroidogenesispor
dc.subjectTeleost.por
dc.subjectEstrogenpor
dc.subjectSparus auratapor
dc.titleGonadal steroidogenesis in response to estradiol-17ß administration in the sea bream (Sparus aurata L.)por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage96por
oaire.citation.issue1por
oaire.citation.startPage82por
oaire.citation.titleGeneral and Comparative Endocrinologypor
oaire.citation.volume124por
person.familyNameCanario
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

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