Publication
The pathways of cell death in cardiomyocytes induced by vanadate
| dc.contributor.author | Aureliano, M. | |
| dc.contributor.author | S. Soares, Sandra | |
| dc.contributor.author | Henao, Fernando | |
| dc.contributor.author | Gutiérrez-Merino, Carlos | |
| dc.date.accessioned | 2012-06-26T11:00:24Z | |
| dc.date.available | 2012-06-26T11:00:24Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | After 24 hours, cardiac myocytes exposure to 10 μM (LD50) vanadate (meta or decavanadate) an increased (30%) of caspase 3-activation was observed, although not significant. On contrary, a significant decrease (40%) of ATP content, characteristic of necrotic cell death was detected. Furthermore, vanadate treatment increased intracellular Ca2+ level from 60 nM to 240 nM, whereas it decreases mitochondria superoxide anion generation and induces mitochondria membrane depolarization (IC50=6.5 μM). In conclusion, micromolar vanadate exposure induces large chances in two major bioenergetic markers in cardiac myocytes: intracellular calcium concentration and superoxide anion mitochondrial production, suggesting a necrotic cell death through a mitochondrial toxic pathway. | por |
| dc.identifier.uri | http://hdl.handle.net/10400.1/1309 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Medimond | por |
| dc.subject | Cell death | por |
| dc.subject | Vanadate | por |
| dc.title | The pathways of cell death in cardiomyocytes induced by vanadate | por |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 16 | por |
| oaire.citation.startPage | 13 | por |
| oaire.citation.title | European Meeting of the Society for Free Radical Research International, Source: Free Radicals, Health and Lifestyle | por |
| person.familyName | Aureliano | |
| person.familyName | Soares | |
| person.familyName | Gutierrez-Merino | |
| person.givenName | Manuel | |
| person.givenName | Sandra | |
| person.givenName | Carlos | |
| person.identifier | 584146 | |
| person.identifier.ciencia-id | AA14-3490-DC5E | |
| person.identifier.orcid | 0000-0003-4858-3201 | |
| person.identifier.orcid | 0000-0002-6562-2674 | |
| person.identifier.orcid | 0000-0003-3673-7007 | |
| person.identifier.rid | I-3283-2012 | |
| person.identifier.rid | K-4574-2014 | |
| person.identifier.scopus-author-id | 6603412860 | |
| person.identifier.scopus-author-id | 10539327200 | |
| rcaap.rights | openAccess | por |
| rcaap.type | conferenceObject | por |
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