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Subcellular partitioning kinetics, metallothionein response and oxidative damage in the marine mussel Mytilus galloprovincialis exposed to cadmium-based quantum dots

2016-06Journal article Restricted access
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dc.contributor.authorRocha, Thiago Lopes
dc.contributor.authorGomes, TĂąnia
dc.contributor.authorDurigon, Emerson Giuliani
dc.contributor.authorBebianno, Maria JoĂŁo
dc.date.accessioned2017-04-07T15:56:38Z
dc.date.available2017-04-07T15:56:38Z
dc.date.issued2016-06
dc.description.abstractThe environmental health impact of metal-based nanomaterials is of emerging concern, but their metabolism and detoxification pathways in marine bioindicator species remain unclear. This study investigated the role of subcellular partitioning kinetics, metallothioneins (MTs) response and oxidative damage (lipid peroxidation LPO) in the marine mussel Mytilus galloprovincialis exposed to CdTe quantum dots (QDs) in comparison with its dissolved counterpart. Mussels were exposed to QDs and dissolved Cd for 21 days at 10 mu g Cd L-1 followed by a 50 days depuration. Higher Cd concentrations were detected in fractions containing mitochondria, nucleus and lysosomes, suggesting potential subcellular targets of QDs toxicity inmussel tissues. Tissue specific metabolism patterns were observed in mussels exposed to both Cd forms. Although MT levels were directly associated with Cd in both forms, QDs subcellular partitioning is linked to biologically active metal (BAM), but no increase in LPO occurred, while in the case of dissolved Cd levels are in the biologically detoxified metal (BDM) form, indicating nano-specific effects. Mussel gills showed lower detoxification capability of QDs, while the digestive gland is the major tissue for storage and detoxification of both Cd forms. Both mussel tissues were unable to completely eliminate the Cd accumulated in the QDs form (estimated half-life time > 50 days), highlighting the potential source of Cd and QDs toxicity for human and environmental health. Results indicate tissue specific metabolism patterns and nano-specific effects in marine mussel exposed to QDs. (C) 2016 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.scitotenv.2016.02.168
dc.identifier.issn0048-9697
dc.identifier.otherAUT: MBE00379
dc.identifier.urihttp://hdl.handle.net/10400.1/9478
dc.language.isoeng
dc.peerreviewedyes
dc.relationMembrane technology to treat effluents with metal nanoparticles
dc.relation.isbasedonWOS:000373274700015
dc.titleSubcellular partitioning kinetics, metallothionein response and oxidative damage in the marine mussel Mytilus galloprovincialis exposed to cadmium-based quantum dots
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMembrane technology to treat effluents with metal nanoparticles
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAAC-AMB%2F121650%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FECM%2F102244%2F2008/PT
oaire.citation.endPage141
oaire.citation.startPage130
oaire.citation.titleScience of the Total Environment
oaire.citation.volume554
oaire.fundingStreamCOMPETE
oaire.fundingStream3599-PPCDT
person.familyNameGomes
person.familyNameBebianno
person.givenNameTĂąnia
person.givenNameMaria
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0001-6179-4543
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
project.funder.nameFundação para a CiĂȘncia e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery71dcd70c-3a6a-45f7-bbe7-6b8a5346cc88
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