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Report of in vitro antileishmanial properties of Iberian macroalgae

2018Journal article Restricted
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dc.contributor.authorBruno De Sousa, Carolina
dc.contributor.authorLago, João Henrique G.
dc.contributor.authorMacridachis, Jorge
dc.contributor.authorOliveira, Marta
dc.contributor.authorBrito, Luis
dc.contributor.authorVizetto-Duarte, C
dc.contributor.authorFlorindo, Claudia
dc.contributor.authorHendrickx, Sarah
dc.contributor.authorMaes, Louis
dc.contributor.authorMorais, Thiago
dc.contributor.authorUemi, Miriam
dc.contributor.authorNeto, Luís
dc.contributor.authorDionísio, Lídia
dc.contributor.authorCortes, Sofia
dc.contributor.authorBarreira, Luísa
dc.contributor.authorCustódio, Luísa
dc.contributor.authorAlberício, Fernando
dc.contributor.authorCampino, Lenea
dc.contributor.authorVarela, João
dc.date.accessioned2020-07-13T09:18:18Z
dc.date.available2020-07-13T09:18:18Z
dc.date.issued2018
dc.description.abstractHere is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.pt_PT
dc.description.sponsorshipFCT: IF/00049/2012/ IF/00743/2015; 00743/2015pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/14786419.2018.1434637pt_PT
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/10400.1/14077
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationMarine photosynthetic organisms of the Algarve coast with biomedical applications
dc.relationMARINE ALGAE EXTRACTS AS A SOURCE OF NATURAL ANTILEISHMANIAL COMPOUNDS
dc.relationBiomedical properties of Cystoseira species: insights into nutra- and pharmaceutical applications
dc.subjectAntiprotozoal agentspt_PT
dc.subjectCarotenoidspt_PT
dc.subjectChromatographypt_PT
dc.subjectDrug evaluationpt_PT
dc.subjectFatty acidspt_PT
dc.subjectLeishmania infantumpt_PT
dc.subjectMagnetic resonance spectroscopypt_PT
dc.subjectPhaeophytapt_PT
dc.subjectSeaweedpt_PT
dc.subjectSteroidspt_PT
dc.subjectGaspt_PT
dc.subjectPreclinicalpt_PT
dc.titleReport of in vitro antileishmanial properties of Iberian macroalgaept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine photosynthetic organisms of the Algarve coast with biomedical applications
oaire.awardTitleMARINE ALGAE EXTRACTS AS A SOURCE OF NATURAL ANTILEISHMANIAL COMPOUNDS
oaire.awardTitleBiomedical properties of Cystoseira species: insights into nutra- and pharmaceutical applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR%2F103957%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F78062%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F81425%2F2011/PT
oaire.citation.endPage1782pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1778pt_PT
oaire.citation.titleNatural Product Researchpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
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person.familyNameBruno de Sousa
person.familyNameMacridachis
person.familyNameOliveira
person.familyNameVizetto-Duarte
person.familyNameFlorindo
person.familyNameNeto
person.familyNameDionísio
person.familyNameBarreira
person.familyNameCustódio
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person.givenNameCarolina
person.givenNameJorge
person.givenNameMarta
person.givenNameCatarina
person.givenNameClaudia
person.givenNameLuís
person.givenNameLídia
person.givenNameLuísa
person.givenNameLuísa
person.givenNameJoão
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person.identifier.ridJ-9538-2015
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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