Repository logo
 
Publication

Reprogramming iPSCs to study age-related diseases: models, therapeutics, and clinical trials

2023Journal article Restricted
Simple item page
dc.contributor.authorEsteves, Filipa
dc.contributor.authorBrito, David
dc.contributor.authorRajado, Ana Teresa
dc.contributor.authorSilva, Nádia
dc.contributor.authorApolónio, Joana
dc.contributor.authorRoberto, Vania Palma
dc.contributor.authorAraújo, Inês Maria
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorCastelo-Branco, Pedro
dc.contributor.authorBragança, José
dc.contributor.authorP. Andrade, Raquel
dc.contributor.authorM. Calado, Sofia
dc.contributor.authorFaleiro, L
dc.contributor.authorMatos, Carlos A
dc.contributor.authorMarques, Nuno
dc.contributor.authorMarreiros, Ana
dc.contributor.authorNzwalo, Hipólito
dc.contributor.authorPais, Sandra
dc.contributor.authorPalmeirim, Isabel
dc.contributor.authorS, Simão
dc.contributor.authorJoaquim, Natércia
dc.contributor.authorMiranda, Rui
dc.contributor.authorPêgas, António
dc.contributor.authorRaposo, Daniela Marques
dc.contributor.authorSardo, Ana
dc.date.accessioned2023-11-08T11:07:38Z
dc.date.available2023-11-08T11:07:38Z
dc.date.issued2023
dc.description.abstractThe unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand health span. The establishment of induced pluripotent stem cells (iPSCs) by reprogramming human somatic cells has revolutionised the modelling and understanding of human diseases. iPSCs have a major advantage relative to other human pluripotent stem cells as their obtention does not require the destruction of embryos like embryonic stem cells do, and do not have a limited proliferation or differentiation potential as adult stem cells. Besides, iPSCs can be generated from somatic cells from healthy individuals or patients, which makes iPSC technology a promising approach to model and decipher the mechanisms underlying the ageing process and age-associated diseases, study drug effects, and develop new therapeutic approaches. This review discusses the advances made in the last decade using iPSC technology to study the most common age-associated diseases, including age-related macular degeneration (AMD), neurodegenerative and cardiovascular diseases, brain stroke, cancer, diabetes, and osteoarthritis.pt_PT
dc.description.sponsorshipALG-01-0145-FEDER-072586pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.mad.2023.111854pt_PT
dc.identifier.issn0047-6374
dc.identifier.urihttp://hdl.handle.net/10400.1/20141
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectIPSCpt_PT
dc.subjectAge-related diseasespt_PT
dc.subjectDisease modellingpt_PT
dc.subjectMechanismspt_PT
dc.subjectTherapeuticspt_PT
dc.titleReprogramming iPSCs to study age-related diseases: models, therapeutics, and clinical trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage111854pt_PT
oaire.citation.titleMechanisms of Ageing and Developmentpt_PT
oaire.citation.volume214pt_PT
person.familyNameEsteves
person.familyNameNeves de Brito
person.familyNameRajado
person.familyNameSilva
person.familyNameApolónio
person.familyNameRoberto
person.familyNamePombinho de Araújo
person.familyNameNóbrega
person.familyNameCastelo-Branco
person.familyNameBragança
person.familyNameAndrade
person.familyNameCalado
person.familyNameFaleiro
person.familyNameAlbuquerque Andrade de Matos
person.familyNameMarques
person.familyNameMarreiros
person.familyNameNzwalo
person.familyNamePais
person.familyNamePalmeirim
person.familyNameSimao
person.givenNameFilipa
person.givenNameDavid Manuel
person.givenNameAna Teresa
person.givenNameNádia
person.givenNameJoana
person.givenNameVânia
person.givenNameInês Maria
person.givenNameClévio
person.givenNamePedro
person.givenNameJosé
person.givenNameRaquel
person.givenNameSofia
person.givenNameMaria Leonor
person.givenNameCarlos Adriano
person.givenNameNuno
person.givenNameAna
person.givenNameHipólito
person.givenNameSandra
person.givenNameIsabel
person.givenNameSonia
person.identifierV-9872-2017
person.identifier1230353
person.identifierF-4703-2012
person.identifier252666
person.identifier337064
person.identifier.ciencia-id4617-D34F-481F
person.identifier.ciencia-idD215-90DC-618A
person.identifier.ciencia-id791E-9E39-2795
person.identifier.ciencia-id681E-40B7-331F
person.identifier.ciencia-idD11F-D4CA-2947
person.identifier.ciencia-idC510-7F41-BAF8
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.ciencia-idAC1D-FA9D-F66F
person.identifier.ciencia-id2312-360B-227A
person.identifier.ciencia-id7C1A-91BA-B6A0
person.identifier.ciencia-id281D-5E01-F09A
person.identifier.ciencia-idDC14-C299-222A
person.identifier.ciencia-id9A12-9450-7051
person.identifier.ciencia-id2C1F-E4F3-2C79
person.identifier.ciencia-id1F1A-ED3C-3260
person.identifier.ciencia-id141A-4DE2-6FF3
person.identifier.orcid0000-0002-3308-8665
person.identifier.orcid0000-0002-3669-3780
person.identifier.orcid0000-0003-2090-4923
person.identifier.orcid0000-0002-9727-1813
person.identifier.orcid0000-0002-8134-4045
person.identifier.orcid0000-0002-2438-0111
person.identifier.orcid0000-0002-8312-5292
person.identifier.orcid0000-0002-3453-3978
person.identifier.orcid0000-0001-9566-400X
person.identifier.orcid0000-0002-0397-5917
person.identifier.orcid0000-0001-5509-4145
person.identifier.orcid0000-0002-3878-6948
person.identifier.orcid0000-0002-9019-7569
person.identifier.orcid0000-0003-0275-2807
person.identifier.orcid0000-0001-9410-4772
person.identifier.orcid0000-0002-1502-3534
person.identifier.orcid0000-0001-8472-4994
person.identifier.orcid0000-0003-2282-7829
person.identifier.orcid0000-0002-0245-0633
person.identifier.ridM-6047-2013
person.identifier.ridK-2202-2016
person.identifier.ridAAG-3931-2020
person.identifier.scopus-author-id41662079600
person.identifier.scopus-author-id27467657800
person.identifier.scopus-author-id56271084100
person.identifier.scopus-author-id24473454000
person.identifier.scopus-author-id6602220001
person.identifier.scopus-author-id7103114918
person.identifier.scopus-author-id56426215600
person.identifier.scopus-author-id6507927018
person.identifier.scopus-author-id57194785077
person.identifier.scopus-author-id36057285600
person.identifier.scopus-author-id56469150800
person.identifier.scopus-author-id6603305227
person.identifier.scopus-author-id24067982400
rcaap.contributor.authoremailjebraganca@ualg.ptpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94cf8d98-1426-47a1-ab24-6559a64c4b72
relation.isAuthorOfPublication895decc1-5b5a-4a0a-9fec-90f285862724
relation.isAuthorOfPublication00b8a92a-7a21-4eb7-8ce5-8196add70b08
relation.isAuthorOfPublicationd2457dab-5134-47d8-be40-20858acd9efb
relation.isAuthorOfPublication01cf2be1-ea9f-4082-bcc6-e50fe4ad9fe1
relation.isAuthorOfPublicationc730a868-0e9f-43e4-a354-10130b30b764
relation.isAuthorOfPublication1d0c21f4-0f4b-4589-8412-fe1079419774
relation.isAuthorOfPublication725ea6f8-1363-4cee-9cf2-5ac7303b3ba9
relation.isAuthorOfPublicationbb25b5ad-1769-42be-a7d3-8fe76215aa23
relation.isAuthorOfPublication27334e02-e955-4939-b9b5-bdee5b5f9328
relation.isAuthorOfPublicationf2d3fc39-a8f6-4d83-9e60-2e2fdfbc2b4a
relation.isAuthorOfPublication950f7df3-f549-497f-9ace-8edd58a83e08
relation.isAuthorOfPublication5361e29a-3b79-4ce8-9f87-0c667d60588d
relation.isAuthorOfPublication31434f2c-76dd-49e4-a78e-324ab36b81bb
relation.isAuthorOfPublication1b66ba1f-d295-4211-b41e-c0f0b622eea0
relation.isAuthorOfPublicationc0a8e5da-26ae-42a8-ab04-fa4df4356375
relation.isAuthorOfPublication287f7d4e-5ad8-4794-b526-c61d32c00446
relation.isAuthorOfPublicationcc90b4e2-ac8a-41d3-afff-7e5d5392bfb7
relation.isAuthorOfPublication19d625d8-5aae-462b-b83a-ad10a155897f
relation.isAuthorOfPublicatione4df724e-8bad-4f99-8e8b-f888b3c93692
relation.isAuthorOfPublication.latestForDiscovery5361e29a-3b79-4ce8-9f87-0c667d60588d

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
1-s2.0-S0047637423000805-main.pdf
Size:
1.87 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ABC2-Artigos (em revistas ou actas indexadas)
FCB2-Artigos (em revistas ou actas indexadas)
FCT2-Artigos (em revistas ou actas indexadas)