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Report of in vitro antileishmanial properties of Iberian macroalgae

2019-06Journal article Open Access
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dc.contributor.authorBruno De Sousa, Carolina
dc.contributor.authorLago, Joao Henrique G.
dc.contributor.authorMacridachis, Jorge
dc.contributor.authorOliveira, Marta
dc.contributor.authorFonseca Brito, Luis
dc.contributor.authorVizetto-Duarte, Catarina
dc.contributor.authorFlorindo, Claudia
dc.contributor.authorHendrickx, Sarah
dc.contributor.authorMaes, Louis
dc.contributor.authorMorais, Thiago
dc.contributor.authorUemi, Miriam
dc.contributor.authorNeto, Luis
dc.contributor.authorDionísio, Lídia
dc.contributor.authorCortes, Sofia
dc.contributor.authorBarreira, Luísa
dc.contributor.authorCustódio, Luísa
dc.contributor.authorAlbericio, Fernando
dc.contributor.authorCampino, Lenea
dc.contributor.authorVarela, J.
dc.date.accessioned2020-07-24T10:52:07Z
dc.date.available2020-07-24T10:52:07Z
dc.date.issued2019-06
dc.description.abstractHere is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8-101.8 mu g/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 mu g/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives. [GRAPHICS] .
dc.description.sponsorshipFoundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology
dc.description.sponsorshipPortuguese National Budget [PTDC/MAR/103957/2008, CCMAR/Multi/04326, GHTM-UID/Multi/04413/2013, SFRH/BD/78062/2011, SFRH/BD/81425/2011, IF/00049/2012, IF/00743/2015]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CAPES
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)National Council for Scientific and Technological Development (CNPq)
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1080/14786419.2018.1434637
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.urihttp://hdl.handle.net/10400.1/14317
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor & Francis Ltd
dc.relationMarine photosynthetic organisms of the Algarve coast with biomedical applications
dc.relationMARINE ALGAE EXTRACTS AS A SOURCE OF NATURAL ANTILEISHMANIAL COMPOUNDS
dc.relationBiomedical properties of Cystoseira species: insights into nutra- and pharmaceutical applications
dc.subjectMeroterpenoids
dc.titleReport of in vitro antileishmanial properties of Iberian macroalgae
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine photosynthetic organisms of the Algarve coast with biomedical applications
oaire.awardTitleMARINE ALGAE EXTRACTS AS A SOURCE OF NATURAL ANTILEISHMANIAL COMPOUNDS
oaire.awardTitleBiomedical properties of Cystoseira species: insights into nutra- and pharmaceutical applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR%2F103957%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F78062%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F81425%2F2011/PT
oaire.citation.endPage1782
oaire.citation.issue12
oaire.citation.startPage1778
oaire.citation.titleNatural Product Research
oaire.citation.volume33
oaire.fundingStream3599-PPCDT
person.familyNameBruno de Sousa
person.familyNameMacridachis
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person.familyNameFonseca Brito
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person.familyNameDionísio
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person.givenNameCarolina
person.givenNameJorge
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person.givenNameLuis
person.givenNameClaudia
person.givenNameLuís
person.givenNameLídia
person.givenNameLuísa
person.givenNameLuísa
person.givenNameJoão
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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