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Genotoxicity of copper oxide and silver nanoparticles in the mussel Mytilus galloprovincialis

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dc.contributor.authorGomes, Tânia
dc.contributor.authorAraújo, Olinda
dc.contributor.authorPereira, Rita
dc.contributor.authorCatarina Almeida, Ana
dc.contributor.authorCravo, Alexandra
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-27T10:10:13Z
dc.date.available2020-04-27T10:10:13Z
dc.date.issued2013
dc.description.abstractThough there is some information on cytotoxicity of copper nanoparticles and silver nanoparticles on human cell lines, there is no information on their genotoxic and cytotoxic behaviour in bivalve molluscs. The aim of this study was to investigate the genotoxic impact of copper oxide and silver nanoparticles using mussels Mytilus galloprovincialis. Mussels were exposed to 10 μg L⁻¹ of CuO nanoparticles and Cu²⁺ and Ag nanoparticles and Ag⁺ for 15 days to assess genotoxic effects in hemocytes using the comet assay. The results obtained indicated that copper and silver forms (nanoparticles and ionic) induced DNA damage in hemolymph cells and a time-response effect was evident when compared to unexposed mussels. Ionic forms presented higher genotoxicity than nanoparticles, suggesting different mechanisms of action that may be mediated through oxidative stress. DNA strand breaks proved to be a useful biomarker of exposure to genotoxic effects of CuO and Ag nanoparticles in marine molluscs.pt_PT
dc.description.sponsorshipFP7-PEOPLE-2009-IRSESpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.marenvres.2012.11.009pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10400.1/13784
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEFEITOS DA EXPOSIÇÃO A NANOPARTÍCULAS NA ESPÉCIE MYTILUS GALLOPROVINCIALIS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectComet Assaapt_PT
dc.subjectCopperpt_PT
dc.subjectDNA damagept_PT
dc.subjectEnvironmental monitoringpt_PT
dc.subjectHemocytespt_PT
dc.subjectMytiluspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectSilverpt_PT
dc.subjectWater pollutantspt_PT
dc.subjectChemicalpt_PT
dc.titleGenotoxicity of copper oxide and silver nanoparticles in the mussel Mytilus galloprovincialispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEFEITOS DA EXPOSIÇÃO A NANOPARTÍCULAS NA ESPÉCIE MYTILUS GALLOPROVINCIALIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F41605%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAAC-AMB%2F121650%2F2010/PT
oaire.citation.endPage59pt_PT
oaire.citation.startPage51pt_PT
oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume84pt_PT
oaire.fundingStreamCOMPETE
person.familyNameGomes
person.familyNameAraujo
person.familyNameAlmeida
person.familyNameCravo
person.familyNameBebianno
person.givenNameTânia
person.givenNameOlinda
person.givenNameAna
person.givenNameAlexandra
person.givenNameMaria
person.identifier.ciencia-id7419-EE20-8039
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0001-6179-4543
person.identifier.orcid0000-0002-9021-8331
person.identifier.orcid0000-0001-8248-0041
person.identifier.orcid0000-0002-2569-3929
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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