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Tailored bacterial co-cultures improve Tisochrysis lutea growth and nutrient profiles under xenic conditions: a new pathway to improve microalgal production

2026Journal article Open access
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datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorSantos, Tamara
dc.contributor.authorda Fonseca Simões, Beatriz
dc.contributor.authorRossetto, Veronica
dc.contributor.authorPereira, Hugo
dc.contributor.authorMaia, Inês Beatriz
dc.contributor.authorOliveira, Marta
dc.contributor.authorEsteves Lopes Navalho, João Carlos
dc.contributor.authorEngelen, Aschwin
dc.contributor.authorVarela, João
dc.date.accessioned2026-01-14T11:26:02Z
dc.date.available2026-01-14T11:26:02Z
dc.date.issued2026
dc.description.abstractThe marine haptophyte Tisochrysis lutea is a valuable source of high-value compounds, including polyunsaturated fatty acids like docosahexaenoic acid, and pigments (e.g., fucoxanthin). However, high production costs and variability remain major challenges for its large-scale application in aquaculture, pharmaceuticals, and biotechnology industries. Therefore, strategies to enhance biomass production and quality are actively explored. In natural environments, T. lutea establishes mutualistic interactions with bacteria to obtain essential nutrients such as vitamin B12, yet the role of bacteria in industrial cultures remains poorly understood. In this study, 145 bacterial strains were isolated and taxonomically identified from industrial T. lutea cultures, with members of the class Gammaproteobacteria and Actinomycetia being the most prevalent. Forty isolates were screened individually in co-culture with T. lutea revealing strain-specific effects on growth and biochemical composition. Seven beneficial strains were used to design 21 tailored bacterial blends. Several consortia enhanced biomass production (up to 74 %) and increased key bioactive compounds, particularly methylcobalamin (up to 300 %). These findings demonstrate the potential of tailored bacterial consortia to enhance T. lutea productivity and nutritional quality under production-relevant xenic conditions, enabling strategic microbiome modulation for specific industrial goals.eng
dc.description.sponsorshipC644915664-00000026,
dc.identifier.doi10.1016/j.crbiot.2025.100361
dc.identifier.issn2590-2628
dc.identifier.urihttp://hdl.handle.net/10400.1/28095
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationMicrobiome-mediated improvement of industrial Chlorella biomass production
dc.relation.ispartofCurrent Research in Biotechnology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMicrobial consortia
dc.subjectMutualistic interactions
dc.subjectMicroalgal microbiomes
dc.subjectVitamin B 12 production
dc.subjectCo-culture strategies
dc.titleTailored bacterial co-cultures improve Tisochrysis lutea growth and nutrient profiles under xenic conditions: a new pathway to improve microalgal productioneng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleMicrobiome-mediated improvement of industrial Chlorella biomass production
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F140143%2F2018/PT
oaire.citation.titleCurrent Research in Biotechnology
oaire.citation.volume11
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSantos
person.familyNameda Fonseca Simões
person.familyNameRossetto
person.familyNamePereira
person.familyNameMaia
person.familyNameOliveira
person.familyNameEsteves Lopes Navalho
person.familyNameEngelen
person.familyNameVarela
person.givenNameTamara
person.givenNameBeatriz
person.givenNameVeronica
person.givenNameHugo
person.givenNameInês Beatriz
person.givenNameMarta
person.givenNameJoão Carlos
person.givenNameAschwin
person.givenNameJoão
person.identifier282781
person.identifier.ciencia-idF819-1920-EE17
person.identifier.ciencia-id331E-84FD-2F34
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person.identifier.ciencia-id911A-9A0C-744D
person.identifier.orcid0000-0001-9008-4436
person.identifier.orcid0000-0002-4267-0315
person.identifier.orcid0000-0002-1369-2099
person.identifier.orcid0000-0002-7509-2216
person.identifier.orcid0000-0001-6793-8026
person.identifier.orcid0000-0002-9579-9606
person.identifier.orcid0000-0003-3101-693X
person.identifier.ridE-9360-2015
person.identifier.ridM-3432-2013
person.identifier.ridM-4223-2013
person.identifier.scopus-author-id54080259900
person.identifier.scopus-author-id6701622770
person.identifier.scopus-author-id55741416000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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