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Localization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralization

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dc.contributor.authorPinto, Jorge
dc.contributor.authorGavaia, Paulo J.
dc.contributor.authorSimes, D
dc.contributor.authorKelsh, R. N.
dc.contributor.authorCancela, Leonor
dc.date.accessioned2014-06-24T08:42:31Z
dc.date.available2014-06-24T08:42:31Z
dc.date.issued2001
dc.description.abstractOsteocalcin (Bone Gla protein, BGP) is a small noncollagenous protein which is synthesized by osteoblasts and odontoblasts and is found exlusively in mineralized bony tissues. Although isolated for the first time in 1978, only recently has a function for this protein been suggested, specifically in controlling hydroxyapatite crystal growth. Appearance of osteocalcin could be linked to the presence of an hydroxyapatite-containing bony skeleton, since the protein was never found in cartilaginous fishes. Furthermore, within its primary sequence the amino acid residues known to be essential for its function are present in fish as well as in mammals, suggesting that function has been conserved over 400 million years of evolution. Taken totgether, these findings prompted us to study in detail the localization of osteocalcin gene expression in fish.por
dc.identifier.citationPinto J.P., Gavaia P.J., Simes D.C., Kelsh R.N., Cancela M.L. 2001. Localization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralization. 27th meeting of the Federation of European Biochemical Societies (FEBS 2001), June 30 - July 5. Lisbon, Portugal.por
dc.identifier.otherAUT: LCA00739
dc.identifier.urihttp://hdl.handle.net/10400.1/4465
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.titleLocalization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralizationpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapor
oaire.citation.title27th meeting of the Federation of European Biochemical Societiespor
person.familyNamePinto
person.familyNameGavaia
person.familyNameSimes
person.familyNameCancela
person.givenNameJorge
person.givenNamePaulo
person.givenNameDina
person.givenNameM. Leonor
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0003-1501-458X
person.identifier.orcid0000-0002-9582-1957
person.identifier.orcid0000-0002-5145-4753
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridJ-7827-2013
person.identifier.ridA-6470-2011
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id8656187600
person.identifier.scopus-author-id6507104377
person.identifier.scopus-author-id7201884723
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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relation.isAuthorOfPublication.latestForDiscovery84f2bfd8-21d5-42f9-ab9b-510e975ce7f1

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