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Towards cost-effective and sustainable media formulations for terrestrial and aquatic cellular agriculture

2026-07-14Artigo científico Acesso aberto
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datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorLeber, Regina
dc.contributor.authorRosa, Joana
dc.contributor.authorLaizé, Vincent
dc.contributor.authorFernando, Gonçalo F.
dc.contributor.authorBuyel, Johannes
dc.contributor.authorFuchs, Aleksandra
dc.date.accessioned2026-09-29T13:28:34Z
dc.date.available2026-09-29T13:28:34Z
dc.date.issued2026-07-14
dc.description.abstractOver a decade of research on media for cultured meat and seafood production has resulted in multiple highly efficient serum-free and chemically defined formulations for some species, but it has also identified challenges yet to be solved—especially for aquatic cell lines. Depending on the product and cell type, the approach to develop highly efficient, sustainable, and low-priced media can diverge greatly. In this review, we provide an in-depth overview of this complex research area to facilitate strategic decision-making for stakeholders. We evaluate the advantages and limitations of utilizing hydrolysates, growth factor mutants, growth factor alternatives, and stabilizers in serum-free media formulations published for cultured meat production, as well as ongoing research efforts on developing adequate media for cultured seafood. We critically analyze strategies aimed at reducing medium costs and enhancing sustainability of cultured meat and seafood production, including their food-compatibility assessment. We summarize topics that require further exploration, such as identification of species-specific growth factors—particularly for aquatic species; exploration of hydrolysates as a substitute for basal medium; waste medium recycling strategies; and the potential application of artificial intelligence (AI) and machine learning (ML) technologies to enhance these areas. Additionally, we consider possible emerging regulatory issues and their impact on media formulation development. Finally, key performance indicators for media formulations are proposed to guide future strategic and operational improvements regarding an economical and sustainable production process.eng
dc.identifier.doi10.3390/foods15142494
dc.identifier.issn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.1/29543
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofFoods
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCultured meat
dc.subjectCultured seafood
dc.subjectCellular agriculture
dc.subjectSerum free media formulations
dc.subjectCost reduction strategies
dc.subjectKey performance indicators
dc.titleTowards cost-effective and sustainable media formulations for terrestrial and aquatic cellular agricultureeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04326/2020
oaire.awardNumberLA/P/0101/2020
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue14
oaire.citation.titleFoods
oaire.citation.volume15
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRosa
person.familyNameLaizé
person.givenNameJoana
person.givenNameVincent
person.identifier.ciencia-id0B18-8AEC-875C
person.identifier.orcid0000-0001-7947-2681
person.identifier.orcid0000-0001-9565-9198
person.identifier.ridB-4463-2008
person.identifier.scopus-author-id36505067900
person.identifier.scopus-author-id6602982778
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication181f1017-5086-40dc-9edc-a289aaa2d263
relation.isAuthorOfPublicationb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
relation.isAuthorOfPublication.latestForDiscovery181f1017-5086-40dc-9edc-a289aaa2d263
relation.isProjectOfPublicationfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f
relation.isProjectOfPublication794d4c77-c731-471e-bc96-5a41dcd3d872
relation.isProjectOfPublication.latestForDiscoveryfafa76a6-2cd2-4a6d-a3c9-772f34d3b91f

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