A carregar...
Publicação
Basal progenitors as drivers of neocortical expansion
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 784.96 KB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
The diversification and expansion of distinct progenitor cell subtypes during embryogenesis are essential to form the sophisticated brain structures present in vertebrates. In particular, the emergence of highly proliferative basal progenitors contributed to the evolutionary enlargement of the mammalian neocortex. Basal progenitors are at the center of indirect neurogenesis and can be divided into two main subtypes: the classical TBR2-positive intermediate progenitor cells and the outer radial glial cells, which are especially abundant in gyrencephalic species. While the function of some transcriptomic regulators is conserved across the mammalian clade, recent studies have identified human-specific genes and enhancers that uniquely affect progenitor biology, possibly driving the increased neocortical complexity and disease-susceptibility of the human brain. Here, we review the evolution of basal progenitors, highlighting species-specific traits, molecular drivers of proliferation, and how imbalances in neurogenesis contribute to human brain disorders.
Descrição
Palavras-chave
Contexto Educativo
Citação
Editora
Elsevier
Licença CC
Sem licença CC