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Immunocytotoxicity, cytogenotoxicity and genotoxicity of cadmium-based quantum dots in the marine mussel Mytilus galloprovincialis

2014-10Journal article Restricted access
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dc.contributor.authorLopes Rocha, Thiago
dc.contributor.authorGomes, Tânia
dc.contributor.authorCardoso, Cátia
dc.contributor.authorLetendre, Julie
dc.contributor.authorPinheiro, José Paulo
dc.contributor.authorSerrão Sousa, Vânia
dc.contributor.authorRibau Teixeira, Margarida
dc.contributor.authorBebianno, Maria
dc.date.accessioned2020-04-23T13:36:35Z
dc.date.available2020-04-23T13:36:35Z
dc.date.issued2014-10
dc.description.abstractThere is an increased use of Quantum Dot (QDs) in biological and biomedical applications, but little is known about their marine ecotoxicology. So, the aim of this study was to investigate the possible immunocytotoxic, cytogenotoxic and genotoxic effects of cadmium telluride QDs (CdTe QDs) on the marine mussel Mytilus galloprovincialis. Mussels were exposed to 10 μg L(-1) of CdTe QDs or to soluble Cd [Cd(NO3)2] for 14 days and Cd accumulation, immunocytotoxicity [hemocyte density, cell viability, lysosomal membrane stability (LMS), differential cell counts (DCC)], cytogenotoxicity (micronucleus test and nuclear abnormalities assay) and genotoxicity (comet assay) were analyzed. Results show that in vivo exposure to QDs, Cd is accumulated in mussel soft tissues and hemolymph and induce immunotoxic effects mediated by a decrease in LMS, changes in DCC, as well as genotoxicity (DNA damage). However, QDs do not induce significant changes in hemocytes density, cell viability and cytogenetic parameters in opposition to Cd(2+). Soluble Cd is the most cytotoxic and cytogenotoxic form on Mytilus hemocytes due to a higher accumulation of Cd in tissues. Results indicate that immunotoxicity and genotoxicity of CdTe QDs and Cd(2+) are mediated by different modes of action and show that Mytilus hemocytes are important targets for in vivo QDs toxicity.pt_PT
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq) 239524/2012-8pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.marenvres.2014.07.009pt_PT
dc.identifier.issn0141-1136
dc.identifier.urihttp://hdl.handle.net/10400.1/13773
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141113614001366?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNanoparticlespt_PT
dc.subjectCadmium telluride quantum dotspt_PT
dc.subjectImmunotoxicitypt_PT
dc.subjectDNA damagept_PT
dc.subjectHemocytept_PT
dc.subjectMytilus galloprovincialispt_PT
dc.titleImmunocytotoxicity, cytogenotoxicity and genotoxicity of cadmium-based quantum dots in the marine mussel Mytilus galloprovincialispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAAC-AMB%2F121650%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.citation.endPage37pt_PT
oaire.citation.startPage29pt_PT
oaire.citation.titleMarine Environmental Researchpt_PT
oaire.citation.volume101pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream3599-PPCDT
person.familyNameLopes Rocha
person.familyNameGomes
person.familyNameCardoso
person.familyNameLetendre
person.familyNamePinheiro
person.familyNameSerrão Sousa
person.familyNameRibau Teixeira
person.familyNameBebianno
person.givenNameThiago
person.givenNameTânia
person.givenNameCátia
person.givenNameJulie
person.givenNameJosé Paulo
person.givenNameVânia
person.givenNameMargarida
person.givenNameMaria
person.identifier.ciencia-id3D18-B03F-52FB
person.identifier.ciencia-id9111-87FB-26AA
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-0551-6842
person.identifier.orcid0000-0001-6179-4543
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person.identifier.orcid0000-0001-8579-3916
person.identifier.orcid0000-0001-7925-9733
person.identifier.orcid0000-0002-3800-1688
person.identifier.orcid0000-0002-2153-3282
person.identifier.orcid0000-0003-1492-8566
person.identifier.ridA-3864-2015
person.identifier.ridI-9235-2014
person.identifier.ridE-8402-2013
person.identifier.ridB-9012-2012
person.identifier.scopus-author-id37007842200
person.identifier.scopus-author-id24460211000
person.identifier.scopus-author-id35838299700
person.identifier.scopus-author-id8988625600
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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