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A new subfamily of ionotropic glutamate receptors unique to the echinoderms with putative sensory role

2021Journal article Open access
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dc.contributor.authorSania, Rubaiyat E.
dc.contributor.authorCardoso, João
dc.contributor.authorLouro, Bruno
dc.contributor.authorMarquet, Nathalie
dc.contributor.authorCanario, Adelino
dc.date.accessioned2021-11-10T18:20:03Z
dc.date.available2021-11-10T18:20:03Z
dc.date.issued2021
dc.description.abstractChemosensation is a critical signalling process in animals and especially important in sea cucumbers, a group of ecologically and economically important marine echinoderms (class Holothuroidea), which lack audio and visual organs and rely on chemical sensing for survival, feeding and reproduction. The ionotropic receptors are a recently identified family of chemosensory receptors in insects and other protostomes, related to the ionotropic glutamate receptor family (iGluR), a large family of membrane receptors in metazoan. Here we characterize the echinoderm iGluR subunits and consider their possible role in chemical communication in sea cucumbers. Sequence similarity searches revealed that sea cucumbers have in general a higher number of iGluR subunits when compared to other echinoderms. Phylogenetic analysis and sequence comparisons revealed GluH as a specific iGluR subfamily present in all echinoderms. Homologues of the vertebrate GluA (aka alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, AMPA), GluK (aka kainate) and GluD (aka delta) were also identified. The GluN (aka N-methyl-d-aspartate, NMDA) as well as the invertebrate deuterostome subfamily GluF (aka phi) are absent in echinoderms. The echinoderm GluH subfamily shares conserved structural protein organization with vertebrate iGluRs and the ligand binding domain (LBD) is the most conserved region; genome analysis indicates evolution via lineage and species-specific tandem gene duplications. GluH genes (named Grih) are the most highly expressed iGluRs subunit genes in tissues in the sea cucumber Holothuria arguinesis, with Griha1, Griha2 and Griha5 exclusively expressed in tentacles, making them candidates to have a chemosensory role in this species. The multiple GluH subunits may provide alternative receptor assembly combinations, thus expanding the functional possibilities and widening the range of compounds detected during aggregation and spawning in echinoderms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1111/mec.16206pt_PT
dc.identifier.issn0962-1083
dc.identifier.urihttp://hdl.handle.net/10400.1/17311
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.subjectChemosensory receptorspt_PT
dc.subjectEchinodermspt_PT
dc.subjectIonotropic glutamate receptorspt_PT
dc.subjectPhylogenypt_PT
dc.subjectSea cucumberpt_PT
dc.titleA new subfamily of ionotropic glutamate receptors unique to the echinoderms with putative sensory rolept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.titleMolecular Ecologypt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCardoso
person.familyNameLouro
person.familyNameMarquet
person.familyNameCanario
person.givenNameJoão
person.givenNameBruno
person.givenNameNathalie
person.givenNameAdelino
person.identifier14332
person.identifierN-6804-2013
person.identifier143624
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id5613-BBCD-0EFE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0001-8164-581X
person.identifier.orcid0000-0002-3718-4478
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridM-4151-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id16028940200
person.identifier.scopus-author-id57193647721
person.identifier.scopus-author-id56568523700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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