Publication
Fitoquímica no tratamento da artrite reumatoide
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.53 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A artrite reumatoide é uma doença autoimune sistémica crónica, caracterizada por inflamação sinovial, o que se traduz na destruição progressiva da cartilagem articular e dos ossos, e se não tratada, resulta em dor forte, edema, rigidez, perda de função articular, deformidade e incapacidade. Apresenta uma prevalência de 0,5 a 1% nos países Europeus e nos Estados Unidos da América, sendo mais prevalente no sexo feminino.
A etiologia e a fisiopatologia exatas desta doença ainda não são totalmente compreendidas, todavia acredita-se que interações complexas entre o sistema imunológico, fatores ambientais, genética e fatores epigenéticos estejam envolvidos na patogénese da mesma.
Segundo a Sociedade Portuguesa de Reumatologia, o diagnóstico deve ser realizado o mais precoce possível, o qual se baseia, principalmente, em manifestações clínicas, exames laboratoriais e radiográficos, por forma a iniciar rapidamente o tratamento, que tem como objetivo principal atingir a remissão da doença .
Atualmente existe uma ampla gama de medicamentos disponível para o tratamento da artrite reumatoide, porém estes estão associados a uma diversidade de efeitos colaterais indesejáveis, como distúrbios gastrointestinais, cardiovasculares e imunodeficiência, além de que alguns deles são bastante caros.
Assim sendo, os pesquisadores procuram terapias alternativas ou auxiliares, como os produtos obtidos a partir de plantas com atividade anti-inflamatória/antioxidante, porque estas contêm substâncias biologicamente ativas, que apresentam um grande potencial como agentes terapêuticos para a artrite reumatoide, quer sejam isolados, quer em combinação com certos fármacos antiartríticos convencionais.
Rheumatoid arthritis is a chronic systemic autoimmune disease, characterized by synovial inflammation, which translates into the progressive destruction of joint cartilage and bones, and if left untreated, results in severe pain, swelling, stiffness, loss of joint function, deformity and inability. It has a prevalence of 0.5 to 1% in European countries and the United States of America, being more prevalent in females. The exact etiology and pathophysiology of this disease are not yet fully understood, however it is believed that complex interactions between the immune system, environmental factors, genetics, and epigenetic factors are involved in its pathogenesis. According to Portuguese Society of Rheumatology, the diagnosis should be made as early as possible, which is based, mainly, on clinical manifestations, laboratory and radiographic exams, in order to quickly start the treatment, whose main objective is to achieve remission of the disease. Actually, there is a wide range of drugs available for the treatment of rheumatoid arthritis, but these are associated with a variety of undesirable side effects, such as gastrointestinal disorders, cardiovascular and immunodeficiency, and some of them are quite expensive. Therefore, researchers are looking for alternative or auxiliary therapies, such as products obtained from plants with anti-inflammatory/antioxidant activity, because they contain biologically active substances, which have great potential as therapeutic agents for rheumatoid arthritis, whether isolated, or in combination with certain conventional antiarthritic drugs
Rheumatoid arthritis is a chronic systemic autoimmune disease, characterized by synovial inflammation, which translates into the progressive destruction of joint cartilage and bones, and if left untreated, results in severe pain, swelling, stiffness, loss of joint function, deformity and inability. It has a prevalence of 0.5 to 1% in European countries and the United States of America, being more prevalent in females. The exact etiology and pathophysiology of this disease are not yet fully understood, however it is believed that complex interactions between the immune system, environmental factors, genetics, and epigenetic factors are involved in its pathogenesis. According to Portuguese Society of Rheumatology, the diagnosis should be made as early as possible, which is based, mainly, on clinical manifestations, laboratory and radiographic exams, in order to quickly start the treatment, whose main objective is to achieve remission of the disease. Actually, there is a wide range of drugs available for the treatment of rheumatoid arthritis, but these are associated with a variety of undesirable side effects, such as gastrointestinal disorders, cardiovascular and immunodeficiency, and some of them are quite expensive. Therefore, researchers are looking for alternative or auxiliary therapies, such as products obtained from plants with anti-inflammatory/antioxidant activity, because they contain biologically active substances, which have great potential as therapeutic agents for rheumatoid arthritis, whether isolated, or in combination with certain conventional antiarthritic drugs
Description
Keywords
Artrite reumatoide Doença autoimune Etiologia Inflamação Plantas