Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/2099
Título: Chitosan and its derivatives as nanocarriers for siRNA delivery
Autor: Al-Qadi, Sonia
Grenha, Ana
Remuñán-López, Carmen
Palavras-chave: Chitosan
Chitosan derivatives
Formulation parameters
Gene silencing
Nanocarriers
siRNA delivery
Data: 2012
Resumo: The ability to specifically silence genes using siRNA has enormous potential for treating genetic diseases. However, siRNA instability and biodistribution issues still need to be overcome, and adequate delivery vehicles have proven indispensable in conveying siRNA to its target. Chitosan is a promising biopolymer for siRNA delivery, its interest stemming from its safety, biodegradability, mucoadhesivity, permeation enhancing effect and cationic charge, as well as amenability to undergo chemical modifications. Chitosan and its derivatives can be readily arranged into complexes or nanoparticles able to entrap and carry siRNA. Specific strategies have been adopted to improve chitosan-based vectors with regard to transfectability. However, further efforts are required to verify their value and adapt them to enhance therapeutic output prior to clinical application. This review emphasizes the potential of chitosan and its derivatives to develop nanocarriers for siRNA delivery. The properties of chitosan that are significant for transfectability and the most relevant findings are assessed.
Peer review: yes
URI: http://hdl.handle.net/10400.1/2099
Versão do Editor: http://www.jddst.com/product.php?id_product=860
Aparece nas colecções:FCT2-Artigos (em revistas ou actas indexadas)

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Al-Qadi et al. 2012 - Journal of Drug Deliv sci Technol.pdf519,12 kBAdobe PDFVer/Abrir


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