Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/3865
Título: Evidence that olfactory sensitivities to calcium and sodium are mediated by different mechanisms in the goldfish Carassius auratus
Autor: Hubbard, Peter
Canario, Adelino V. M.
Palavras-chave: Olfaction
Data: 2007
Editora: Elsevier
Citação: Hubbard, Peter C.; Canário, Adelino V.M. Evidence that olfactory sensitivities to calcium and sodium are mediated by different mechanisms in the goldfish Carassius auratus, Neuroscience Letters, 414, 1, 90-93, 2007.
Resumo: The current study investigated whether the olfactory sensitivity to Ca2+ and Na+ is mediated by the same mechanism in the goldfish, a freshwater teleost. The olfactory responses, as assessed by recording the electro-encephalogram (EEG) from the olfactory bulb, to changes in external [Ca2+] and to [Na+] were recorded in the absence and presence of increasing concentrations of the other ion. Low concentrations of Na+ (0–1.0 mM) had no significant effects on the olfactory response to changes in [Ca2+] in terms of EC50, Imax or Hill co-efficient (n = 8). A relatively high concentration of Na+ (10 mM) significantly reduced the Imax and increased the EC50. One hundred millimolars Na+reduced the olfactory response to Ca2+ to undetectable levels. Conversely, low concentrations of Ca2+ (0.1 and 1.0 mM) significantly attenuated the olfactory response to changes in environmental [Na+], reducing the amplitude of response and increasing the threshold of detection (n = 7). However, a high concentration of Ca2+ (10 mM) failed to attenuate the olfactory response to Na+ completely. Taken together, these results suggest that, at normal environmental concentrations of these ions, Ca2+ and Na+ are detected by distinct and separate cellular mechanisms. However, there seems to be a degree of overlap between the two mechanisms. The exact mechanisms involved, and their biological roles, remain to be established.
Peer review: yes
URI: http://hdl.handle.net/10400.1/3865
DOI: http://dx.doi.org/10.1016/j.neulet.2006.12.007
ISSN: 0304-3940
Aparece nas colecções:CCM2-Artigos (em revistas ou actas indexadas)

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.