Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.1/4284
Título: Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts
Autor: Rafael, M. S.
Laizé, Vincent
Florindo, C.
Ferraresso, Serena
Bargelloni, Luca
Cancela, Leonor
Data: Mai-2012
Editora: Elsevier
Citação: Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts, Biochimie, 94, 5, 1128-11, 2012.
Resumo: FHL2 is a multifunctional protein involved in gene transcription regulation and cytoarchitecture modulation that has been recently associated with epithelial-mesenchymal transition (EMT) in colon cancer. Overexpression of FHL2 in a fish pre-osteoblastic cell line promoted cell dedifferentiation and impaired its extracellular matrix mineralization capacity. Cell cultures also acquired a novel threedimensional structure organization, their proliferation rate was enhanced and gene expression profile was altered in agreement with an EMT-like phenotype upon overexpression of FHL2. Altogether, our results provide additional support to the relevance of FHL2 for cell differentiation and its association with hallmarks of cancer phenotype.
Peer review: yes
URI: http://hdl.handle.net/10400.1/4284
DOI: http://dx.doi.org/10.1016/j.biochi.2012.01.013
ISSN: 0300-9084
Versão do Editor: http://ac.els-cdn.com/S0300908412000156/1-s2.0-S0300908412000156-main.pdf?_tid=1e976124-f238-11e3-9c1c-00000aab0f26&acdnat=1402581039_97e7a82e70e678d0ac976f0d05c9d4fc
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