Sapientia

UAlg Scientific Repository

About Sapientia

The SAPIENTIA repository gathers an exhaustive set of Algarve University's (UAlg) teachers and researchers scientific publications with an express goal of maximising its visibility, ensure easy and universal access and amelliorate the overall public impact of the university scientific endeavors, as well as the ongoing preservation of its memory.

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Recent Submissions

Clinical outcomes of percutaneous coronary intervention in chronic total occlusion in patients with type 2 diabetes mellitus

Publication . Costa, Hugo; Espírito-Santo, Miguel; Bispo, João; Guedes, João; Mimoso, Jorge; Palmeiro, Hugo; Gonçalves, Rui Baptista; Vinhas, Hugo

Introduction and Objectives: Coronary chronic total occlusions (CTOs) are relatively common findings in patients with type 2 diabetes mellitus (T2DM). However, the indication for percutaneous coronary intervention (PCI) and its clinical benefit in these patients remain controversial. Methods: A single-center retrospective cohort study with prospectively collected outcomes was carried out with CTO patients undergoing PCI in 2019 and 2020. Patients were divided into two groups according to previous T2DM diagnosis (T2DM and non-T2DM). The primary outcome was recurrence of angina and/or heart failure symptoms and secondary outcomes were myocardial infarction and all -cause mortality. Results: A total of 177 patients (82.5% male) were included in the analysis, with a mean age of 65 +/- 11 years. The primary outcome (total symptom recurrence) occurred in 16.6% of the sample, with no difference between groups (non-T2DM 13.6% vs. T2DM 21.2%, p=0.194) in a two-year follow-up. Angina recurrence was significantly more frequent in T2DM patients (15.2%, p=0.043). The presence of T2DM was not an independent predictor of symptom recurrence (p=0.429, HR 1.37, 95% CI 0.62 - 2.98). Myocardial infarction and all -cause mortality were also not different between groups (T2DM 1.5%, p=0.786 and 4.5%, p=0.352, respectively, on survival analysis). Independent predictors of all -cause mortality were left ventricular function and creatine clearance (p=0.039, HR 0.92, 95% CI 0.85 - 0.99 and p=0.013, HR 0.96, 95% CI 0.93 - 0.99, respectively). Conclusions: T2DM did not influence outcomes in CTO patients undergoing PCI, and its presence should not be a limiting factor in deciding on CTO revascularization.

2024-04Journal article

Open Access

Chlamydia trachomatis and Neisseria gonorrhoeae detection: Comparing the recommended detection methods and the ones used in a regional hospital laboratory

Publication . Ling, T.; Pereira, A.; Loureiro, A.; Silva, M. J.

Sexually Transmitted Infections (STI) are a group of infections that spread primarily through unprotected sexual contact and can cause serious consequences if not treated. STIs continue to be a significant public health issue with a direct impact in the sexual health of millions of people worldwide.

2024-05Conference object

Restricted

Clinical results of percutaneous coronary intervention in chronic total occlusions of the right coronary artery

Publication . Costa, Hugo; Espirito-Santo, Miguel; Bispo, João; Guedes, João; Mimoso, Jorge; Palmeiro, Hugo; Gonçalves, Rui Baptista; Vinhas, Hugo

Introduction and Objectives: Coronary chronic total occlusions (CTOs) of the right coronary artery (RCA) are a relatively common finding in the context of coronary angiography. However, the benefit of revascularization remains controversial. Methods: A single -center retrospective cohort analysis prospectively collected outcomes of CTO patients undergoing percutaneous coronary intervention (PCI) in 2019 and 2020. Patients were divided into two groups according to the CTO vessel treated (left coronary artery [LCA]-CTO or RCA-CTO). The primary outcome was defined as the recurrence of angina and/or heart failure (HF) symptoms and secondary outcomes were myocardial infarction (MI) and all -cause mortality. Results: A total of 177 patients (82.5% male) were included in the analysis, with a mean age of 65 +/- 11 years. The primary outcome occurred in 28 (16.6%) patients and was significantly more frequent in RCA-CTO patients (19, 24.7%, p=0.010) in a mean follow-up of 18 months. This was mainly driven by recurrence of HF symptoms (12, 15.6%, p=0.013). Treated RCA-CTO was an independent predictor of the primary outcome (p=0.019, HR 2.66, 95% CI 1.17-6.05). MI and mortality rates were no different between groups (RCA-CTO with 1.3%, p=0.361 and 2.6%, p=0.673, respectively, on survival analysis). Left ventricular ejection fraction was an independent predictor of mortality (p=0.041, HR 0.93, 95% CI 0.87-0.99). Conclusions: Revascularization of CTO lesions by PCI was associated with low rates of symptom recurrence, and clinical outcomes showed no differences regardless of which artery was treated. Recanalization of RCA-CTO was less beneficial in reducing the recurrence of HF symptoms.

2024-03Journal article

Open Access

Anorectal melanoma: a rare entity

Publication . Relvas, Luís Miguel; Gago, Tânia; Velasco, Francisco; Barros, Sónia; Carvalho, Isabel; Caldeira, Paulo

Anorectal melanoma is a rare malignant tumor with the potential of simulating a benign anorectal disease, making its diagnosis difficult. We describe a case of anorectal melanoma, in which the interpretation of symptoms as hemorrhoidal disease delayed diagnosis and appropriate intervention.

2024Letter to the editor

Open Access

Vitamin and micronutrient excess in patients with Crohn’s disease under oral ambulatory exclusive enteral nutrition

Publication . Oliveira, R.; Mendes, B.; Neves, J. Cunha; Amorim, E.; Roseira, J.; Sousa, H. Tavares de

Exclusive enteral nutrition (EEN) is recommended for preoperative nutritional optimization (PNO) in adult Crohn's disease (CD) patients. However, during ambulatory oral EEN, a lack of routine monitoring for vitamins may occur, with a potential risk of hypervitaminosisrelated toxicity, which remains unexplored. This study aims to assess the serum levels of vitamins and micronutrients in CD patients undergoing EEN and to examine its potential impact.

2024-01-01Journal article

Open Access