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Browsing by Author "De Mello, Ramon Andrade"

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  • 49P Impact of nutritional factors in response and survival of patients with gestational trophoblastic neoplasia
    Publication . Roque Perez, K.; Galvez Nino, M.A.; Castro, M.W.; Vallejos, H.D.; Ruiz, R.E.; Valdiviezo Lama, N.I.; Coanqui Gonzales, O.; Olivera, M.; Perez, J.; Lopez, A.; Velarde, C.; De Mello, Ramon Andrade; Mas Lopez, L.A.
    Gestational trophoblastic neoplasia (GTN) is a rare tumor with an excellent prognosis. Despite the International Federation of Gynecology and Obstetrics (FIGO) risk score, other factors that may influence survival remain unknown.
    2022Journal article Restricted access Show more
  • An estimate of the economic impact of immunotherapy relative to PD-L1 expression in Brazil - An update with brazilian costs
    Publication . Aguiar, Pedro, Jr.; De Mello, Ramon Andrade; Tadokoro, Hakaru; Babiker, Hani; Lopes, Gilberto
    Delivering high quality cancer care at an affordable cost is one of the main challenges for health care professionals and policy makers, especially in lowand middle-income countries. The objective of our study is to assess the economic impact of nivolumab and pembrolizumab with and without the use of PD-L1 as a biomarker in Brazil.
    2017-01Conference object Open access Show more
  • Angiogenesis and apatinib: a new hope for patients with advanced gastric cancer?
    Publication . De Mello, Ramon Andrade; de Oliveira, Jailson; Antoniou, Georgios
    2017-02Other Open access Show more
  • Anti-EGFR monoclonal antibodies plus chemotherapy in the first-line treatment of advanced NSCLC: a meta-analysis
    Publication . Stock, Gustavo; Aguiar, Pedro, Jr.; Santoro, Ilka; Tadokoro, Hakaru; De Mello, Ramon Andrade; Lopes, Gilberto
    2017-01Conference object Open access Show more
  • BARX2/FOXA1/HK2 axis promotes lung adenocarcinoma progression and energy metabolism reprogramming
    Publication . Xie, Kai; Feng, Jian; Fan, Dingwei; Wang, Shi; Luo, Jing; Ren, Zhijian; Zheng, Chao; Diao, Yifei; De Mello, Ramon Andrade; Tavolari, Simona; Brandi, Giovanni; Roden, Anja C.; Ren, Binhui; Shen, Yi; Xu, Lin
    Background: Metabolic reprogramming is an emerging cancer feature that has recently drawn special attention since it promotes tumor cell growth and proliferation. However, the mechanism of the Warburg effect is still largely unknown. This research aimed to reveal the effects of BarH-like homeobox 2 (BARX2) in regulating tumor progression and glucose metabolism in lung adenocarcinoma (LUAD).Methods: Expression of BARX2 was measured by quantitative real-time polymerase chain reaction (qRTPCR) in LUAD cell line and tissues, and the tumor-promoting function of BARX2 in LUAD cells was detected in vitro and in vivo xenograft models. The metabolic effects of BARX2 were examined by detecting glucose uptake, the production levels of lactate and pyruvate, and the extracellular acidification rate (ECAR). Chromatin immunoprecipitation (ChIP) assay and luciferase reporter gene assay were used to identify the underlying molecular mechanism of BARX2 regulation of HK2. Further studies showed that transcription factor FOXA1 directly interacts with BARX2 and promotes the transcriptional activity of BARX2.Results: BARX2 was remarkably up-regulated in LUAD tissues and positively linked to advanced clinical stage and poor prognosis. In vitro and in vivo data indicated ectopic expression of BARX2 enhanced cell proliferation and tumorigenesis, whereas BARX2 knockdown suppressed these effects. Metabolic-related experiments showed BARX2 promoted the reprogramming of glucose metabolism. Mechanistically, the BARX2/FOXA1/HK2 axis promoted LUAD progression and energy metabolism reprogramming.Conclusions: In summary, our research first defined BARX2 as a tumor-promoting factor in LUAD andthat it may act as a novel prognostic biomarker and new therapeutic target for the disease.
    2022Journal article Restricted access Show more
  • Cetuximab plus platinum-based chemotherapy in head and neck Squamous Cell Carcinoma: a retrospective study in a single Comprehensive European Cancer Institution
    Publication . De Mello, Ramon Andrade; Gerós, Sandra; Alves, Marcos Pantarotto; Moreira, Filipa; Avezedo, Isabel; Dinis, Jose
    Background: The use of cetuximab in combination with platinum (P) plus 5-fluorouracil (F) has previously been demonstrated to be effective in the treatment of metastatic squamous cell cancer of head and neck (SCCHN). We investigated the efficacy and outcome of this protocol as a first-line treatment for patients with recurrent or metastatic disease. We evaluated overall-survival (OS), progression-free-survival (PFS), overall response rate (ORR) and the treatment toxicity profile in a retrospective cohort. Patients and Methods: This study enrolled 121 patients with untreated recurrent or metastatic SCCHN. The patients received PF+ cetuximab every 3 weeks for a maximum of 6 cycles. Patients with stable disease who received PF+ cetuximab continued to receive cetuximab until disease progressed or unacceptable toxic effects were experienced, whichever occurred first. Results: The median patient age was 53 (37-78) years. The patient cohort was 86.8% male. The addition of cetuximab to PF in the recurrent or metastatic setting provided an OS of 11 months (Confidential Interval, CI, 95%, 8.684-13.316) and PFS of 8 months (CI 95%, 6.051-9.949). The disease control rate was 48.9%, and the ORR was 23.91%. The most common grade 3 or 4 adverse events in the PF+ cetuximab regimen were febrile neutropenia (5.7%), skin rash (3.8%) and mucosistis (3.8%). Conclusions: The results of this study suggest that cetuximab plus platinum-fluorouracil chemotherapy is a good option for systemic treatment in advanced SSCHN patients. This regimen has a well-tolerated toxicity profile.
    2014-02Journal article Open access Show more
  • Comparative cost-effectiveness analysis of avelumab plus axitinib versus pembrolizumab plus axitinib, ipilimumab plus nivolumab, and sunitnib for advanced renal cell carcinoma in the UK perspective
    Publication . De Mello, Ramon Andrade; Ayoub, Emili; Castelo-Branco, Pedro; De Almeida Zia, Victor Andre; Savio, Andre; Pozza, Daniel Humberto; Tadokoro, Hakaru; Teich, Nelson
    2020-02Conference object Restricted access Show more
  • Comparative Outcome Assessment of EGFR TKIs for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Network Meta-Analysis
    Publication . De Mello, Ramon Andrade; Aguiar, Pedro, Jr.; Cabral, Paloma; Chaves, Fablo; Liu, Davi; Soares, João Paulo; Mountzios, Giannis; Tadokoro, Hakaru; Lopes, Gilberto de Lima
    2017-01Conference object Restricted access Show more
  • COVID-19 vaccinations: summary guidance for Cancer patients in 28Languages: breaking barriers to Cancer patient Information
    Publication . Mauri, Davide; Kamposioras, Konstantinos; Tsali, Lampriani; Dambrosio, Mario; De Bari, Berardino; Hindi, Nadia; Salembier, Carl; Nixon, Joanna; Dimitrios, Tzachanis; Alongi, Flippo; Hameed, Hassan; Valachis, Antonios; Papadimitriou, Konstantinos; Corradini, Stefanie; Popovic, Lazar; Kopecky, Jindrich; Rodriguez, Andres; Antunac, Katarina; Yi, Junlin; Lovey, Jozsef; Strojan, Primoz; Saraireh, Haytham; Røtterud, Ranveig; Chojnacka, Marzanna; Olalla, Santa Cruz; Chilingirova, Natalia; De Mello, Ramon Andrade; Amaral, Giovanna Araujo; Arbabi, Farsid; Vidra, Radu; Rapushi, Erjeta; Takeuchi, Dan; Christopoulos, Chirstos; Ivanova, Irina; Djan, Igor; Petricevic, Branka; Cellini, Francesco; Mihaylova, Iglika; Plavetic, Natalija Dedic; Kuhar, Cvetka Grašič; Takeuchi, Elena; Kountourakis, Pantelis; Ntellas, Panagiotis; Gazouli, Ioanna; Gkoura, Stefania; Yuce, Salih; ER, Özlem; Yasmina, Chait; Kumaran, Gireesh; Spahiu, Orges; Yusuf, Aasim; Gono, Paulina; Apostolidis, Kathi; Tolia, Maria
    Background: Covid-19 vaccination has started in the majority of the countries at the global level. Cancer patients are at high risk for infection, serious illness, and death from COVID-19 and need vaccination guidance and support. Guidance availability in the English language only is a major limit for recommendations' delivery and their application in the world's population and generates information inequalities across the different populations. Methods: Most of the available COVID-19 vaccination guidance for cancer patients was screened and scrutinized by the European Cancer Patients Coalition (ECPC) and an international oncology panel of 52 physicians from 33 countries. Results: A summary guidance was developed and provided in 28 languages in order to reach more than 70 percent of the global population. Conclusion: Language barrier and e-guidance availability in the native language are the most important barriers when communicating with patients. E-guidance availability in various native languages should be considered a major priority by international medical and health organizations that are communicating with patients at the global level.
    2022Journal article Open access Show more
  • CRISPR-based strategies in infectious disease diagnosis and therapy
    Publication . Binnie, Alexandra; Fernandes, Emanuel; Almeida‑Lousada, Helder; De Mello, Ramon Andrade; Castelo-Branco, Pedro
    CRISPR gene-editing technology has the potential to transform the diagnosis and treatment of infectious diseases, but most clinicians are unaware of its broad applicability. Derived from an ancient microbial defence system, these so-called "molecular scissors" enable precise gene editing with a low error rate. However, CRISPR systems can also be targeted against pathogenic DNA or RNA sequences. This potential is being combined with innovative delivery systems to develop new therapeutic approaches to infectious diseases.
    2021Journal article Open access Show more