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Percorrer por autor "Palma, Pedro"

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  • Clinical and epidemiological characteristics of patients with functional stroke mimics: a case–control study from Southern Portugal
    Publication . Figueira Domingos, Miguel; Silva, Vítor Hugo; Schuh, Sara; Correia, Helena; Palma, Pedro; Pedro, João Pedroso; Nova, Bruno Vila; Marreiros, Ana; Félix, Ana Catarina; Nzwalo, Hipólito
    Background: Patients with functional neurological disorder presenting as stroke mimics or functional stroke mimics (FSMs) pose significant diagnostic challenges. In the acute phase, especially when patients are present within the therapeutic window for acute reperfusion treatments, a misdiagnosis of FSM can lead to unnecessary and costly interventions. Despite its clinical importance, the literature on the risk factors for FSM is limited. This study aims to compare the clinical and epidemiological characteristics of patients with FSM to those with confirmed acute ischemic stroke (AIS). Methods: This case-control study involved temporal matching between consecutive series of patients with FSM and controls with AIS from a single tertiary university hospital in southern Portugal. Results: A total of 188 patients were included: 64 cases (FSM) and 188 controls (AIS). The rate of stroke code activation and use of ambulance between was comparable between the two groups. The group of patients with FSM was younger (53.2 years vs. 69.5 years, p < 0.001) and had a higher proportion of females (52.4% vs. 47.6%, p = 0.001). There was no difference in terms of clinical severity at presentation. The proportion of specific signs, such as transcortical aphasia (3.1% vs. 20.9%, p = 0.014), gait abnormalities (15.6% vs. 33.9%, p = 0.004), and cranial nerve abnormalities (31.2% vs. 43.5%, p = 0.042), was lower in the FSM group compared to the AIS group. The proportion of patients on antithrombotic therapy (90.9% vs. 9.1%, p = 0.007) and antihypertensive drugs (78.5%, vs. 21.5%, p < 0.001) prior to the event was significantly higher in the AIS group. Likewise, the prevalence of cerebrovascular risk factors such as diabetes mellitus (14.3% vs. 85.7%, p = 0.005), arterial hypertension (23.8% vs. 76.2%, p = 0.001), and smoking (43.7% vs. 56.3%, p = 0.005) was lower in the FSM group compared to the AIS group. No statistically significant differences were observed in cholesterol levels or the prevalence of dyslipidemia between the two groups. Psychiatric comorbidities, including generalized anxiety disorder (71.4% vs. 28.6%, p = 0.05) and major depressive disorder (61.9% vs. 28.1%, p = 0.01), were more prevalent in the FSM group. Conclusions: Patients with FSM display different clinical and epidemiological profiles, with a higher likelihood of being younger, female, having prior psychiatric conditions, and lacking traditional cerebrovascular risk factors.
    2025-02-07Artigo científico Acesso aberto Ver mais
  • Nitração de tirosinas na miosina: consequências funcionais
    Publication . Palma, Pedro; Aureliano, M.
    Tem sido demonstrado que o biomarcador 3-nitrotirosina (3-NT), frequentemente utilizado na reactividade do peroxinitrito (ONOO-) com as proteínas, aumenta na miosina após fibrilação atrial [Mihm et al, 2001b, 2003; Kooy et al, 1997] e durante o envelhecimento [Kansky et al, 2005a, 2005b; Hong et al, 2007].
    2008Trabalho de fim de curso Acesso aberto Ver mais
  • Peroxynitrite-mediated oxidative modifications of myosin and implications on structure and function
    Publication . Tiago, Teresa; Palma, Pedro; Gutiérrez-Merino, Carlos; Aureliano, M.
    The peroxynitrite-induced functional impairment of myosin was studied in different reaction conditions, known to alter the oxidative chemistry of peroxynitrite, to better understand the molecular mechanisms of this interaction. It is shown that peroxynitrite is able to enhance the basal MgATPase activity up to 2-fold while inhibiting the actin-stimulated ATPase activity of myosin and that the extent of these functional alterations is dependent on the reaction medium. The observed changes in the stimulation of the MgATPase activity correlate with the extent of carbonyl formation in myosin. The enzyme inhibition is more potent in conditions where the effi ciency of tyrosine nitration and peroxynitrite reactivity towards sulphydryls are lower. Together with the observation that reversion of sulphydryl oxidation did not lead to the recovery of myosin functional and structural impairments, these results point out to the importance of protein carbonylation as a post-translational modifi cation in the peroxynitrite-induced myosin functional impairment.
    2010Artigo científico Acesso restrito Ver mais