Browsing by Issue Date, starting with "2025-02-26"
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- Validation and psychometric properties of the portuguese version of the Freiburg Mindfulness Inventory (FMI)Publication . Iacob, Vivien; Carmo, Cláudia; Garcês, Soraia; Chiodelli, Roberto; Walach, Harald; Neves de Jesus, SaúlThis research aimed to develop a Portuguese version of the Freiburg Mindfulness Inventory (FMI) short form and investigate its psychometric properties through two complementary studies. The first study included a sample of 337 participants. It analyzed the scale's internal consistency, reliability, and factorial validity by conducting an exploratory and confirmatory factor analysis using a randomly divided sample of the general population. The second study examined the convergent and concurrent validity, temporal stability, and sensitivity to change in the FMI among participants in an Interculturality and Mindfulness program (n = 150). The results indicated high internal consistency and reliability for the Portuguese version of FMI (omega = 0.87). The exploratory and confirmatory factor analysis reinforced the instrument's unidimensional solution. The findings supported the convergent and concurrent validity, temporal stability, and sensitivity to change. The translated version's psychometric qualities are satisfactory and can be used to assess mindfulness in the Portuguese population.
- Induced pluripotent stem cell-derived mesenchymal stem cells for modeling and treating metabolic associated fatty liver disease and metabolic associated steatohepatitis: challenges and opportunitiesPublication . Marques da Silva, Barbara Sofia; Bragança, JoséThe potential of induced pluripotent stem cells (iPSCs) for modeling and treating metabolic associated fatty liver disease (MAFLD) and metabolic associated steatohepatitis (MASH) is emerging. MAFLD is a growing global health concern, currently with limited treatment options. While primary mesenchymal stem cells hold promise, iPSCs offer a versatile alternative due to their ability to differentiate into various cell types, including iPSC-derived mesenchymal stem cells. However, challenges remain, including optimizing differentiation protocols, ensuring cell safety, and addressing potential tumorigenicity risks. In addition, iPSCs offer the possibility to generate complex cellular models, including three-dimensional organoid models, which are closer representations of the human disease than animal models. Those models would also be valuable for drug discovery and personalized medicine approaches. Overall, iPSCs and their derivatives offer new perspectives for advancing MAFLD/MASH research and developing novel therapeutic strategies. Further research is needed to overcome current limitations and translate this potential into effective clinical applications.
- An evaluation of the NANDA international, inc., diagnostic classification among spanish nurses: a cross-sectional studyPublication . Rodríguez Suárez, Claudio Alberto; Mariscal Crespo, María Isabel; Hernández de Luis, María Naira; Costa, Emília Isabel; González de la Torre, Héctor; Camacho Bejarano, RafaelaBackground/Objectives: The NANDA International, Inc., (NANDA-I) diagnostic classification is the most widely used standardized nursing language internationally. The EVALUAN-I tool was developed to evaluate the NANDA-I diagnostic classification. The aim was to analyze the use of the NANDA-I diagnostic classification among Spanish nurses and assess its correlation with sociodemographic characteristics. Methods: A cross-sectional study was conducted on a non-probabilistic sample of Spanish nurses working in clinical, management, and academic settings using the EVALUAN-I tool (September 2019-December 2020). The analysis was conducted using R (R) (version 3.6.3, Lavaan package; R Core Team, 2020), with statistical significance set at p < 0.05. This study was approved by the Research Ethics Committee (2019-190-1). Results: A total of 483 responses were obtained. There was a correlation between the intensity of use of NANDA-I and its application in practice (polychoric correlation = 0.50; p < 0.001). Nurses with a PhD degree considered nursing diagnoses to be less evidence-based (p = 0.037) but more useful (p = 0.035). Academic and research nurses stated that NANDA-I was more useful (p = 0.007), even for exclusive responsibilities (p = 0.034), and that it provided greater significance to diagnoses (p = 0.0012). Conclusions: NANDA-I is the most widely used standardized nursing language in Spain. Nurses' academic qualifications and work environment significantly influence their perceptions and use of NANDA-I. Advanced education fosters a critical yet positive perspective, highlighting a relationship between the intensity of its use, its application in clinical practice, and the nurse's educational background. Tools such as EVALUAN-I promote its integration and evidence-based practice, but challenges remain in improving perceptions, scientific evidence, and visibility in electronic health records to enhance its clinical impact and nursing recognition.