Browsing by Issue Date, starting with "2025-04-21"
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- Um passo a seguir ao outro: criação e reflexão artísticaPublication . Gonçalves, Ângelo; Santos , António Pedro Cabral dos; Dourado , Ana Patrícia de Queiroz CarneiroUm passo a seguir ao outro: Criação e reflexão artística é uma investigação sobre o trabalho artístico que produzi desde os anos de 2010 até aos dias de hoje. Com esta pesquisa pretende-se mostrar como o trabalho realizado se relaciona entre os eixos artístico e político, eixos que alimentam todo o processo de criação e que está patente, nomeadamente, nas abordagens artística e teórica, propriamente ditas. Na presente fundamentação, recorremos a um conjunto de obras, esboços e apontamentos realizados nas últimas duas décadas, com o intuito de poder, deste modo, explicitar quais as preocupações patentes no trabalho, entrecruzando-as com o mundo e a sua direção, advindo daí o título que dá o mote a esta reflexão. Um passo a seguir ao outro pretende, assim, mostrar como a produção realizada têm quase sempre como base o “outro” e necessariamente as infinitas possibilidades de como o ser humano e o mundo são explorados/examinados. Deseja-se apresentar, deste modo, os métodos, motivações e processos de criação utilizados nos diversos caminhos percorridos.
- Complement gene expression in the fetal brain after maternal immune activation in a rodent modelPublication . Correia, Édi Pedro; Hoffmann, CarolinThe developmental stage consists of a wide variety of fine-tuned biological processes. Disruptions in these mechanisms may induce alterations in the fetus, compromising its viability or causing malformations and/or deficits. Pathogens such as bacteria and viruses that cross the placenta have been well established as some of these disruptors with some of these being able to directly harm neurodevelopment. However, the immune system cells themselves have also been described as having a key role in the development of the brain being relevant in processes such as the cortical plate formation and neurogenesis. It is also well known that the mother’s health habits and even diseases are likely to be mirrored on the fetus’ development, since it relies on the mother’s organism for survival. Recent studies have dwelled on the maternal immune system and its effects on development being more specifically focused on its activation by inflammatory signals. Maternal Immune Activation (MIA) during development has been described as having a causative relation to neurodevelopmental disorders, such as schizophrenia, autism specter disorder (ASD), anxiety and depression. Experimental models of MIA can reproduce disease biomolecular alterations and behavioral phenotypes in rodent models. Alongside these findings, the complement system – a group of proteins that play a role in the innate immune response – has also been discovered as having a key role in neurodevelopment, mainly in neuron progenitor cells (NPC) proliferation, migration and differentiation. With both MIA and the complement system having roles in neurodevelopment, this project sets out to evaluate the complement gene expression in fetal brain after MIA in the rodent model using bioinformatics to assess differential gene expression, co-expressed genes and the biological processes in which these are involved. Differential gene expression results of this project proved to be consistent with literature while gene ontology enrichment analysis of co-expressed genes resulted in significant neurodevelopmental biological processes.
- Reformulation and characterization of mediterranean ingredients by novel technologiesPublication . Ates, Elif Gokçen; Bal, Murad; Karasu, Melis Cetin; Cifte, Neriman Ezgi; Erdem, Furkan; Gul, Muhammed Rasim; Tas, Ozan; Karsli, Gokcem Tonyali; Pleslić, Sanda; Smokrović, Kristina; Maltar-Strmečki, Nadica; Abiad, Mohamad G.; Dukić, Josipa; Jambrak, Anet Režek; Ngameni Tchonkouang, Rose Daphnee; Vieira, Margarida; Antunes, Maria Dulce; Mert, Behic; Sumnu, Gulum; Alpas, Hami; Oztop, MecitThe Mediterranean diet is known for its health benefits, mainly due to its diverse ingredients, such as fruits, vegetables, grains, nuts, legumes, and olive oil. This review examines the reformulation and characterization of these Mediterranean ingredients using several novel food processing and analytical technologies. Reformulation technologies discussed include microwave pasteurization, microwave vacuum drying (VMD), pulsed electric field (PEF), high-pressure homogenization (HPH), freeze drying, high hydrostatic pressure (HHP), and cold plasma technology (CP). Characterization technologies covered include Nuclear Magnetic Resonance (NMR), Electron Paramagnetic Resonance (EPR), and Near Infrared (NIR) spectroscopy. Nonthermal techniques such as PEF, HHP and CP are particularly noteworthy for their ability to preserve nutritional and sensory qualities without using high temperatures, that can degrade sensitive compounds. The main requirement for these processing methods is to ensure that the food retains its beneficial nutrients and natural flavors while extending its shelf life. Analytical techniques like NMR, EPR, and NIR spectroscopy provide detailed insights into the molecular composition and quality of food products. These techniques allow for precise optimization of processing methods, ensuring the best possible quality and nutritional value. The integration of these advanced processing and analytical techniques with traditional Mediterranean ingredients offers significant advancements in food science, improving food quality, nutritional value, and the sustainability of food production. This review aims to provide a comprehensive understanding of how these novel technologies can be applied to optimize the nutritional and sensory qualities of Mediterranean ingredients while enhancing their health-promoting capabilities.