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Percorrer Faculdade de Economia por Objetivos de Desenvolvimento Sustentável (ODS) "03:Saúde de Qualidade"
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- Antibacterial, antioxidant, and antiproliferative activities of corymbia citriodora and the essential oils of eight eucalyptus speciesPublication . Miguel, Maria da Graça; Gago, Custódia; Estêvão, Maria Dulce da Mota Antunes de Oliveira ; Lagoas, Soraia; Faleiro, Maria Leonor; Megías, Cristina; Cortés-Giraldo, Isabel; Vioque, Javier; Figueiredo, Ana CristinaBackground: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC). Antibacterial activity was evaluated using the microorganisms Streptococcus pneumoniae (strains D39 and TIGR4), and Haemophilus influenza (strain DSM 9999). The essential oils’ minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was assessed using a microdilution method. The antiproliferative activity was determined using the THP-1 cell line (human acute monocytic leukaemia) with methylthiazolyldiphenyl-tetrazolium bromide assay (MTT). Results: Corymbia citriodora and Eucalyptus viminalis EOs showed the highest ABTS and peroxyl free radical scavenging capacity. Eucalyptus globulus EO showed a high potential to treat Streptococcus pneumoniae infections. Haemophilus influenzae was the respiratory pathogen that showed the highest resistance to all EOs, including tea tree EO. After 96 h of incubation, at 25 µg/mL, Eucalyptus radiata and Eucalyptus viminalis EOs showed highest cytotoxic activity against the THP-1 cell line. Conclusions: Despite their specific bioactivities, no single EO showed simultaneously good antioxidant, antimicrobial, and antiproliferative activity.
- Minute city concept for healthy tourism during the COVID-19 pandemic crisis. who for? The city of Lagos, PortugalPublication . Pires Rosa, Manuela; Lopes, Ana; Aghaeizadeh, Esmaeil; Gomes, André; Andraz, JorgeUrban spatial organization provided an important contribution for healthy tourism in the first COVID-19 pandemic period. The 15-Minute City concept promotes walking which is essential for the development of outdoor activities for a healthier tourism. The tourist city of Lagos (Portugal) is a pilot city of the Interreg Med SuSTowns Project which aims to promote sustainable and resilient territories. This study presents an analysis of the pedestrian accessibility through a specific geographical indicator: the percentage of short-term rentals existing in the surrounding tourist attractions. Ideal standard distances, studied internationally, were considered to assess this close proximity. Different walking speeds were considered to address human diversity and their implications on the 15-Minute City concept. The functionalities of the geographic information systems, in particular the assessment of distances over the pedestrian network were used. The results indicate that in the city of Lagos there is a trend towards an effective 15-Minute City for healthy tourists, promoting walking which could enhance tourism attraction. For tourists with reduced mobility, the use of accessible public transportation is required and needs to be integrated in the 15-Minute City concept.