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- Avaliação do potencial das Tiazolidinedionas como estratégia terapêutica no MelanomaPublication . Espírito Santo, Margarida; De Sousa-Coelho, Ana Luísa; Ana Patrícia, PintoO melanoma é uma doença mundial que representa a forma mais agressiva de cancro da pele com incidência e mortalidade em contínuo aumento. Apesar de existirem terapêuticas direcionadas às mutações específicas no melanoma, a resistência adquirida pelos doentes ao tratamento constitui uma barreira ao sucesso da terapêutica, suscitando assim a necessidade de identificação de novos fármacos e novas opções terapêuticas. Nos últimos anos tem surgido grande interesse na potencial utilização de antidiabéticos orais, como a metformina (biguanida) no tratamento do melanoma. As tiazolidinedionas (TZDs), agonistas do receptor PPARγ, são também uma classe de fármacos utilizados no tratamento da diabetes tipo 2.
- Qualitative assessment of cardiovascular risk in a community pharmacy in the AlgarvePublication . Espírito Santo, Margarida; Reis, Joana; Nascimento, TâniaCardiovascular diseases are the leading cause of death worldwide and several risks factors can be identified in the etiology.
- Hepatitis C treatment in a district HospitalPublication . Espírito Santo, Margarida; Guerreiro, Luisa; Nascimento, TâniaThe aim of this study was the characterization of patients with Hepatitis C (HCV) under treatment. Patients included in this study were followed in a Portuguese District Hospital between January 2012 and September 2014, have received treatment for HCV and who had at least one infectiology consultation in this period. Data were collected from the hospital computer system, and patient´s data were collected anonymously, without patient identification. Data analysis was performed using SPSS v22.0. Were included in this study 87 patients who met the inclusion criteria, 75% (n=65) were males and 25% (n=22) female, with a mean age of 45±10 years. Most patients included in this study were Portuguese, resident in the Hospital district and nearby districts. Patients were diagnosed with HCV with a mean age of 3311 years, were followed on average for 53.5 years in this Hospital, and were diagnosed with HCV on average 126.9 years ago. Among these patients, 44% (n=38) had genotype 1, 2% (n=2) genotype 2, 17% (n=15) genotype 3, 13% (n=11) genotype 4 and 24% (n=21) with unknown genotype. Most frequent treatment regimens used by patients included in the study were the association of pegylated interferon alfa 2b (100mcg/week) and ribavirin (1000 mg/day) (52%; n=45); pegylated interferon alpha 2a (180mcg/week) and ribavirin (1000 mg/day) (42%; n=36). Other associations were used but less frequently: pegylated interferon alfa 2a + ribavirin + boceprevir (2%; n=2); pegylated interferon alfa 2b + ribavirin + boceprevir (3%; n=3); and pegylated interferon alfa 2a + ribavirin + telaprevir (1%; n=1). Among included patients, 55 (63%) have performed, to date, one treatment for HCV, 19 (22%) have performed two treatments for HCV (using two different regimens or by using the same regimen twice), 9 (10%) already underwent treatment three times, 3 (3%) already underwent treatment four times and only one patient (1%) has conducted five treatments for HCV. Excluding patients who were receiving treatment at the time of data collection (September 2014), the average length of all other treatments performed by the patients was 82 months, and most (40%; n=51) of treatments performed by patients had a duration from 6 to 9 months. From the results, the standard treatment for patients with HCV appears to be in accordance with the existing guidelines for the treatment of this pathology. In the future it would be advisable further analysis and extended to other hospitals to assess the degree of compliance with currently existing national guidelines for the treatment of this pathology.
- Medication adherence and cardiometabolic control in type 2 diabetesPublication . Espírito Santo, Margarida; Gomes, Eurico; Nascimento, Tânia; Puerta Vázquez, Rocío; Arche, María-ÁngelesDiabetes mellitus type 2 is a disease that affects 12.9% of individuals in Portugal and whose control is difficult to achieve. Non-adherence to diabetes treatment is probably one of the causes of uncontrolled diabetes.
- Health literacy assessment: Translation and cultural adaptation to the Portuguese populationPublication . Espírito Santo, Margarida; Nascimento, Tânia; Pinto, Ezequiel; De Sousa-Coelho, Ana Luísa; Newman, JeffHealth literacy (HL) has been widely referenced as a determinant of health outcomes, making the assessment of low HL a fundamental step to plan educational interventions. This study aimed to translate and adapt the Short Assessment of Health Literacy-Spanish and English (SAHL-S&E) questionnaire into European Portuguese.
- How diabetics’ patients identify their medicines?Publication . Espírito Santo, Margarida; Nascimento, Tânia; Newman, JeffThe main goal of this study was the characterization of diabetic patients´ knowledge in the identification of medicines, respectively the drug´s name, drug´s strength, and therapeutic indication. A cross-sectional study was developed at a specialized medical center in the diabetes area. Only patients that accepted to participate in this research and who gave their consent in writing before the start of the study were enrolled. In the study they were included patients aged 18 years and older, with diagnosis of diabetes mellitus, and using at least one medicine. Data collection was conducted through structured interviews, which was held during a consultation in a systematic way by completion of a questionnaire. Were included in this study one hundred and seven (107) patients, 41.1% female and 58.9% male, aged between 35 and 88 years, with a mean age of 65.6±10.5 years. The most prevalent health problems, beside diabetes mellitus, were hypertension (83.2%) and dyslipidaemia (74.8%), with a mean of 4.7±1.9 health problems per patient. Each patient was using a mean of 6.9±2.9 medicines and 0.2±0.4 food supplements per day. The therapeutic group often used was C (Cardiovascular System), A (Alimentary Tract and Metabolism) and N (Nervous System) with respectively 33.8%, 32.6% and 11.5%. Patients included in this study could not indicate the name of the medicines they were taking in 50% of the medicines, but were able to read the name of the medicine in most (96.5%) of them. When patients were questioned regarding drug´s strength only in about 25% of the medicines they managed to indicate the respective value. In most medicines (67.7%), patients were able to indicate the correct therapeutic indication for each medicine, although in 16.8% of medicines patients did not know the respective therapeutic indication, in 9.2% of medicines the information about therapeutic indication was incomplete, and in 6.3% of medicines patients have indicated an incorrect therapeutic indication. The results obtained indicate that patients have some lack of ability in the basic identification of the medicines used. In the future it will be desirable to perform a more extensive analysis that includes further variables related to the knowledge of the patients about medicines, including instructions of use, possible side effects and storage conditions, in order to be able to establish an action plan that can provide patients with more and better skills to achieve a responsible use of medicines.
- Colorectal cancer prevention: strategies for promoting literacyPublication . Espírito-Santo, Margarida; Gomes, Tânia; Nascimento, TâniaBackground Colorectal cancer (CRC) is the most frequent and deadly cancer in Portugal, prevention and early detection with screening are key factors for decreasing the incidence of CRC and improving survival rates. CRC screenings allow the detection of benign situations and their remotion, preventing the development of a malignant condition. Thus, this study aimed to identify strategies that could promote CRC literacy in order to also increase the number of screenings. Methods A systematic review (SR) was performed using PICOS methodology to define study goals and then PRISMA methodology to collect data for the review, including intervention studies published from 2010. Results A final number of 11 articles were included in this SR, which used several strategies to promote literacy. These studies included patients mostly within the age range of 50–75 years. The different strategies identified contained delivering pamphlets, seminars, using technological solutions, among others. All of these educational strategies led to the breaking down of some barriers that might exist about screening and bowel preparation, which conduced to an increase in adherence to CRC screening. Since most of the studies were performed in populations presenting low health literacy or belonging to ethnic minorities, strategies such as verbal information sessions showed better results. Conclusions Several strategies seems to be effective, since the results of different interventions have translated into increased CCR literacy and also the number of screenings. Portuguese pharmacy professionals, given easy access and user confidence can contribute directly, as a future perspective, in the education of patients with CCR.
- Characterization of the biologic therapy used by patients with Psoriasis and Psoriatic Arthritis treated in HDS.Publication . Espírito Santo, Margarida; Lopes, João; Alves, AnaPsoriasis is chronic, immune-mediated, infflamatory, multi-system disease, which manifests predominantly in the skin and at the joint.
- Adequação terapêutica da utilização de inibidores da bomba de protões: estudo exploratórioPublication . Espírito Santo, Margarida; De Sousa-Coelho, Ana Luísa; Duarte, Denise; Nascimento, TâniaO aumento acentuado do consumo de fármacos inibidores da bomba de protões (IBPs) que se tem verificado nos últimos cinco anos fez surgir a necessidade de analisar a sua utilização na prática clínica atual e avaliar as possíveis consequências associadas ao seu consumo. Pretendeu-se com este estudo analisar a adequação terapêutica da utilização de IBPs na prática clínica de uma farmácia comunitária.
- Diabetes self-care and disease knowledgePublication . Espírito-Santo, Margarida; Nascimento, Tânia; Gomes, EuricoDiabetes mellitus (DM), presenting as a chronic metabolic pathology, is multifactorial and factors such as self-care can positively contribute to the glycemic control. Allied with patient’s behaviour, the knowledge about this disease may empower patient´s to achieve appropriate disease management including treatment adherence and avoidance of complications.
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