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- Retrospective study of cisplatin plus radiotherapy toxicities in locally advanced squamous cell carcinoma of the head and neck – ReCisTT studyPublication . Gomes, Ana; Castro, Gilberto; Oliveira, Thiago Bueno de; Colmenero, Ana Medina; Ribeiro, Leonor; Psyrri, Amanda; Magné, Nicolas; Serrahima, Maria Plana; Marinho, Joana; Giglio, Raul; Rey, Leticia Iglesias; Angel, Martín; Macedo, AnaIntroduction Squamous cell carcinoma of the head and neck (SCCHN) is a multifactorial disease involving genetic and environmental factors representing one of the most frequent cancer-related deaths worldwide. Tobacco and alcohol use account for most SCCHN, while a growing subset of oropharyngeal cancers is causally associated with human papillomavirus (HPV) infection. Despite improvements in overall survival, patients with HPV-negative locally advanced (LA) SCCHN continue to have a poor prognosis. For these patients, the standard of care is radiotherapy with concurrent chemotherapy (RCT).Methods This retrospective, multicenter, and observational study analyzed the treatment compliance of 326 patients with LA-SCCHN who underwent RCT between January 1st, 2014, and June 30th, 2017. This study also evaluated the potential factors associated with treatment compliance, the compliance impact on clinical response, and the main toxicities experienced by patients.Results A total of 274 (84%) patients were compliant and received the planned dose of cisplatin. Overall, 957 adverse events were reported in 98.2% of patients during the study. The overall response rate was 80.2%, with 60.4% of patients achieving a complete response.Discussion Despite the high treatment compliance, 62.6% of adverse events reported were related to cisplatin. Identifying risk factors associated with non-compliance could enable physicians to identify ineligible patients for cisplatin-based RCT and prevent patients from receiving inadequate treatment leading to severe adverse events.
- A new diatom species from a transitional environment (Arade river estuary, Portugal): Tetramphora witkowskii sp. nov.Publication . Gomes, Ana; Hamilton, Paul Brian; Solak, Cüneyt Nadir; Boski, Tomasz; Moura, Delminda; Ertorun, Nesil; Yedidağ, FerhanDue to the environmental complexity created by physical and chemical gradients, transitional biomes host a large biological diversity. There has been some effort to better understand the diversity of diatoms living in these transitional environments, although many diatom species remain undescribed from these habitats. Gathering this knowledge will significantly improve our ability to halt biodiversity loss due to anthropogenic activities and assess individual water bodies' ecological status. More detailed studies on diatoms from transitional environments will also further enhance the research that uses them as proxies to reconstruct past environmental changes. The current research documents a new diatom species from the genus Tetramphora, found on the saltmarshes of the Arade River Estuary (Southern Portugal), and its autecology. As with the other twelve recognised species of the genus, Tetramphora witkowskii sp. nov. presents an asymmetrical valve outline, a biarcuate raphe system, slit like areolae, axial costae, a central hyaline area, and a dorsal central thickening. Tetramphora witkowskii sp. nov. is characterised by having finely silicified valves with a nearly flat face, 28.0-33.0 mu m in length and 6.0-6.5 mu m in width. The new species has a stria density of 24-27 in 10 mu m with narrow, longitudinally oriented areola openings. It presents proximal raphe endings covered by a projected dorsal-side flap and a developed sternum with thickened costae, weakly formed on the dorsal side of the central area. Tetramphora witkowskii sp. nov. was found as a benthic epipelic diatom with a preference for brackish to salt water with circumneutral pH. Further research is required to better understand this species' colony and frustule shape, the number, morphology, and position of the chloroplasts, genetic signature, geographical distribution, and environmental tolerance.