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Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector

2016Journal article Open access
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dc.contributor.authorOliveira, Ana V.
dc.contributor.authorMarcelo, Adriana
dc.contributor.authorCosta, Ana M. Rosa da
dc.contributor.authorSilva, Gabriela A.
dc.date.accessioned2016-01-11T11:21:59Z
dc.date.available2016-01-11T11:21:59Z
dc.date.issued2016
dc.description.abstractA successful gene therapy approach can prevent or treat congenital and acquired diseases. However, there is still no ideal non-viral vector for gene delivery in a safe and timely manner. In this report the anionic polymer hyaluronic acid (HA) was investigated as a potential vector for gene therapy. Due to its intrinsic characteristics it constitutes an excellent candidate to deliver therapeutic genes, pending the modification of its surface charge.pt_PT
dc.description.sponsorshipPEst-OE-QUI-UI4023-2014; PIRG-GA-2009-249314
dc.identifier.citationMater. Sci. Eng. C, 58, 2016, 264–272pt_PT
dc.identifier.doihttp://dx.doi.org/ 10.1016/j.msec.2015.08.047pt_PT
dc.identifier.issn0928-4931
dc.identifier.otherAUT: GAS02236; AMC01695;
dc.identifier.urihttp://hdl.handle.net/10400.1/7408
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDEVELOPMENT OF NON-VIRAL VECTORS FOR GENE THERAPY FOR PATHOLOGIES OF THE RETINA
dc.subjectGene therapypt_PT
dc.subjectHyaluronic acidpt_PT
dc.subjectPolymer modificationpt_PT
dc.subjectRetinapt_PT
dc.subjectBiocompatibilitypt_PT
dc.titleEvaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vectorpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDEVELOPMENT OF NON-VIRAL VECTORS FOR GENE THERAPY FOR PATHOLOGIES OF THE RETINA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-BEB%2F098475%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70318%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0023%2F2013/PT
oaire.citation.endPage272pt_PT
oaire.citation.startPage264pt_PT
oaire.citation.titleMaterials Science and Engineering Cpt_PT
oaire.citation.volume58pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameMarcelo
person.familyNameRosa da Costa
person.givenNameAdriana
person.givenNameAna M
person.identifier305029
person.identifier.ciencia-id7613-00C2-1621
person.identifier.ciencia-idA418-A85E-5DB1
person.identifier.orcid0000-0002-7327-0170
person.identifier.orcid0000-0003-0225-9537
person.identifier.ridE-2165-2012
person.identifier.scopus-author-id53986075100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication0ca8c16f-6881-4662-bafc-cc51c5ce8d88
relation.isAuthorOfPublication.latestForDiscovery3bed3cc3-e36a-445b-8d7d-4d4615ff4c4c
relation.isProjectOfPublication610cf07c-9c35-43ca-933b-27e8122a5fcd
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