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Publicação
Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector
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Orientador(es)
Resumo(s)
A successful gene therapy approach can prevent or treat congenital and acquired diseases. However, there is still no ideal non-viral vector for gene delivery in a safe and timely manner. In this report the anionic polymer hyaluronic acid (HA) was investigated as a potential vector for gene therapy. Due to its intrinsic characteristics it constitutes an excellent candidate to deliver therapeutic genes, pending the modification of its surface charge.
Descrição
Palavras-chave
Gene therapy Hyaluronic acid Polymer modification Retina Biocompatibility
Contexto Educativo
Citação
Mater. Sci. Eng. C, 58, 2016, 264–272
Editora
Elsevier