Evaluation of cystamine-modified hyaluronic acid/chitosan polyplex as retinal gene vector

Oliveira, Ana V.; Marcelo, Adriana; Costa, Ana M. Rosa da; Silva, Gabriela A.

http://hdl.handle.net/10400.1/7408

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Materials Science and Engineering C 58 (2016) 264–272.pdf		1.25 MB	Adobe PDF	Download

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Authors

Oliveira, Ana V.

Marcelo, Adriana

Costa, Ana M. Rosa da

Silva, Gabriela A.

Abstract(s)

A successful gene therapy approach can prevent or treat congenital and acquired diseases. However, there is still no ideal non-viral vector for gene delivery in a safe and timely manner. In this report the anionic polymer hyaluronic acid (HA) was investigated as a potential vector for gene therapy. Due to its intrinsic characteristics it constitutes an excellent candidate to deliver therapeutic genes, pending the modification of its surface charge.