Repository logo
 
Publication

Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish

2006Journal article Restricted access
Simple item page
dc.contributor.authorVan der Ven, Leo
dc.contributor.authorVan den Brandhof, Evert-Jan
dc.contributor.authorVos, José H.
dc.contributor.authorPower, Deborah
dc.contributor.authorWester, Piet W.
dc.date.accessioned2014-10-24T09:04:15Z
dc.date.available2014-10-24T09:04:15Z
dc.date.issued2006
dc.description.abstractSome ubiquitous pollutants of the aquatic environment, such as PCBs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. In a partial life cycle assay with zebrafish (Danio rerio), we studied the effects of the reference compound propylthiouracil (PTU) on reproduction, growth and development, histopathology of some target tissues, and plasma thyroid hormone levels. PTU induced a concentration-dependent increase of egg production with a concomitant decrease of mature oocyte size but had no effect on fertilization rate or hatching.por
dc.description.sponsorshipPiet Beekhof, Bhawani Nagarajah, Sisca de Vlugt, Joke Robinson, and Sandra de Waal are acknowledged for their dedicated technical assistance, and Dr. Saskia Sterk (Laboratory for Food and Residue analysis, European Union Community Reference Laboratory, RIVM) is acknowledged for PTUmeasurements. This study was ordered by the European Commission (Project B6-7920/98/00025) and the Dutch Environment Ministry VROM (Project M/640920).por
dc.identifier.citationLeo T.M . Vanderven, Evert-Jan Van den Brandhof, José H. Vos, Deborah Power, Piet W. Wester, "Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish" in Environ. Sci. Technol. 2006, 40, 74-81.por
dc.identifier.doihttp://dx.doi.org/10.1021/es050972c
dc.identifier.issn0013-936X
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5449
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherACS Publicationspor
dc.titleEffects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafishpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage81por
oaire.citation.issue1por
oaire.citation.startPage74por
oaire.citation.titleEnvironmental Science & Technologypor
oaire.citation.volume40por
person.familyNamePower
person.givenNameDeborah Mary
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.pdf
Size:
827.35 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.49 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)