Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish

Van der Ven, Leo; Van den Brandhof, Evert-Jan; Vos, José H.; Power, Deborah; Wester, Piet W.

http://hdl.handle.net/10400.1/5449

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish.pdf		827.35 KB	Adobe PDF	Download

Send Feedback

Authors

Van der Ven, Leo

Van den Brandhof, Evert-Jan

Vos, José H.

Power, Deborah

Wester, Piet W.

Abstract(s)

Some ubiquitous pollutants of the aquatic environment, such as PCBs or other polyhalogenated aromatic hydrocarbons, may disrupt the thyroid hormone system. In a partial life cycle assay with zebrafish (Danio rerio), we studied the effects of the reference compound propylthiouracil (PTU) on reproduction, growth and development, histopathology of some target tissues, and plasma thyroid hormone levels. PTU induced a concentration-dependent increase of egg production with a concomitant decrease of mature oocyte size but had no effect on fertilization rate or hatching.

URI

http://hdl.handle.net/10400.1/5449

Citation

Leo T.M . Vanderven, Evert-Jan Van den Brandhof, José H. Vos, Deborah Power, Piet W. Wester, "Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish" in Environ. Sci. Technol. 2006, 40, 74-81.

Publisher

ACS Publications

DOI

http://dx.doi.org/10.1021/es050972c

Collections

CCM2-Artigos (em revistas ou actas indexadas)

Altmetrics

Full item page