Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)

Galay-Burgos, M.; Power, Deborah; Llewellyn, Lynda; Sweeney, Glen E.

http://hdl.handle.net/10400.1/5486

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Abstract(s)

Flatfish such as the Atlantic halibut (Hippoglossus hippoglossus) undergo a dramatic metamorphosis that transforms the pelagic, symmetric larva into a benthic, cranially asymmetric juvenile. In common with amphibian metamorphosis, flatfish metamorphosis is under endocrine control with thyroid hormones being particularly important. In this report we confirm that tri-iodothyronine (T3) levels peak at metamorphic climax during halibut metamorphosis. Moreover we have isolated cDNA clones of TR and TR genes and confirmed the presence in halibut of two TR isoforms (representing the products of distinct genes) and two TR isoforms (generated from a single gene by alternative splicing). Real time PCR was used to assess expression of these genes during metamorphosis. TR shows the most dramatic expression profile, with a peak occurring during metamorphic climax.

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http://hdl.handle.net/10400.1/5486

Citation

Malyka Galay-Burgos, Deborah M. Power, Lynda Llewellyn, Glen E. Sweeney, "Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)" in Molecular and Cellular Endocrinology 281, 1-2 (2007) 56.