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Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)
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Resumo(s)
Flatfish such as the Atlantic halibut (Hippoglossus hippoglossus) undergo a dramatic metamorphosis that transforms the pelagic, symmetric larva into a benthic, cranially asymmetric juvenile. In common with amphibian metamorphosis, flatfish
metamorphosis is under endocrine control with thyroid hormones being particularly
important. In this report we confirm that tri-iodothyronine (T3) levels peak at
metamorphic climax during halibut metamorphosis. Moreover we have isolated cDNA
clones of TR and TR genes and confirmed the presence in halibut of two TR
isoforms (representing the products of distinct genes) and two TR isoforms (generated from a single gene by alternative splicing). Real time PCR was used to assess expression of these genes during metamorphosis. TR shows the most dramatic expression profile, with a peak occurring during metamorphic climax.
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Contexto Educativo
Citação
Malyka Galay-Burgos, Deborah M. Power, Lynda Llewellyn, Glen E. Sweeney, "Thyroid hormone receptor expression during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus)" in Molecular and Cellular Endocrinology 281, 1-2 (2007) 56.
Editora
Elsevier