The effect of smoking on lung function changes during a 16-week combined exercise program in middle-aged workers: a latent growth curve analysis

Gomes Moreira da Silva, Manuela Fernanda; Ferreira, José P.; Teixeira, Ana M.; Monteiro, Diogo; Duarte-Mendes, Pedro

http://hdl.handle.net/10400.1/27347

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Authors

Gomes Moreira da Silva, Manuela Fernanda

Abstract(s)

Purpose To investigate the longitudinal changes in lung function of sedentary middle-aged workers over a 16-week combined exercise training program. Methods Thirty-six sedentary workers (53.70±6.92 years old) were randomly allocated to either a combined aerobic and resistance training program (n=18) or a control group (n=18). Lung function was evaluated through spirometry using a portable fow spirometer (Spiropalm 6MWT, Cosmed, Italy). Predicted percentages of forced vital capacity (FVC), forced expiratory volume in the frst second (FEV1), FEV1/FVC ratio, and mean forced expiratory fow between 25 and 75% of exhaled FVC (FEF25–75) were analyzed. Assessments were performed at baseline (M1), after 8-week (M2) and 16-week follow-up (M3). The changes in lung function were analyzed using the Latent Growth Curve Modeling that estimated interindividual and intraindividual growth paths. Results Smoking status revealed a signifcant efect on lung function growth with signifcant paths to intercept and slope for all models in both groups. The exercise group participants who are non-smokers revealed higher increases in FVC% (β=.22), FEV1% (β=.08), FEV1/FVC% ratio (β=.19), and FEF25–75% (β=.06) compared to those who are smokers from M1 to M3. The control group revealed a lower growth in lung function from M1 to M3, with a lower slope observed in smokers compared to non-smokers for FVC% (β=−.44), FEV1% (β=−.41), FEV1/FVC% (β=−.98), and FEF25–75% (β=−.52). Conclusion Our fndings suggest that a 16-week combined training program is an efective strategy to improve lung function among sedentary workers, with a higher magnitude of improvement for non-smokers compared to smokers. Trial registration Clinicaltrials.gov, NCT04868240. Registered April 30, 2021.