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Retro tIming: A multicentric retrospective analysis of immunotherapy timing in metastatic melanoma

2024-06-01Conference object Restricted
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dc.contributor.authorGonçalves, Lisa
dc.contributor.authorGoncalves, Duarte
dc.contributor.authorCasanelles, Teresa Esteban
dc.contributor.authorGuerra, Laura Pratas
dc.contributor.authorMenezes, Maria B.
dc.contributor.authorBranco, Vanessa Duarte
dc.contributor.authorLuís, Joana Alves
dc.contributor.authorSimões, Filipa
dc.contributor.authorGramaça, João
dc.contributor.authorPinho, Inês S.
dc.contributor.authorBarroso, Tiago
dc.contributor.authorPatel, Vanessa
dc.contributor.authorMartins, Miguel Esperança
dc.contributor.authorBrás, Raquel Lopes
dc.contributor.authorSousa, Rita Teixeira de
dc.contributor.authorMansinho, André
dc.contributor.authorTorres, Sofia
dc.contributor.authorCosta, Luis
dc.date.accessioned2024-12-06T14:05:01Z
dc.date.available2024-12-06T14:05:01Z
dc.date.issued2024-06-01
dc.description.abstractImmune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emerging field as circadian oscillations are observed in the immune landscape (e.g immune cell numbers) as well as in the expression of immunotherapy targets (e.g. PD-1).eng
dc.identifier.doi10.1200/jco.2024.42.16_suppl.9542
dc.identifier.eissn1527-7755
dc.identifier.issn0732-183X
dc.identifier.urihttp://hdl.handle.net/10400.1/26413
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Society of Clinical Oncology
dc.relation.hasversionhttps://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.9542
dc.relation.ispartofJournal of Clinical Oncology
dc.rights.uriN/A
dc.titleRetro tIming: A multicentric retrospective analysis of immunotherapy timing in metastatic melanomaeng
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferenceDate2024-05-29
oaire.citation.conferencePlaceELECTR NETWORK/Special Clinical Science Symposia
oaire.citation.endPage1
oaire.citation.issue16_suppl
oaire.citation.startPage1
oaire.citation.titleJournal of Clinical Oncology
oaire.citation.volume42
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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