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Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression

2012Journal article Restricted access
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dc.contributor.authorCampinho, Marco António
dc.contributor.authorGalay-Burgos, M.
dc.contributor.authorSilva, Nádia
dc.contributor.authorCosta, R. A.
dc.contributor.authorAlves, Ricardo N.
dc.contributor.authorSweeney, Glen E.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-23T17:10:56Z
dc.date.available2014-10-23T17:10:56Z
dc.date.issued2012
dc.description.abstractFlatfish metamorphosis is the most dramatic postnatal developmental event in teleosts. Thyroid hormones (TH), thyroxine (T4) and 3,3′-5′-triiodothyronine (T3) are the necessary and sufficient factors that induce and regulate flatfish metamorphosis. Most of the cellular and molecular action of TH is directed through the binding of T3 to thyroid nuclear receptors bound to promoters with consequent changes in the expression of target genes. The conversion of T4 to T3 and nuclear availability of T3 depends on the expression and activity of a family of 3 selenocysteine deiodinases that activate T4 into T3 or degrade T4 and T3.por
dc.description.sponsorshipWe thank Heiddis Smáradóttir of Fiskeldi Eyjafjarðar, IS-600 Akureyri, Iceland, for providing the halibut samples. This project was supported by the European Community project, LIFECYCLE (222719-2) and the Portuguese Ministry of Science (FCT; project PDCT/MAR/115005/2009). M.A.C. was sponsored by the Portuguese Ministry of Science (grant no. SFRH/BPD/66808/2009).por
dc.identifier.citationM. A. Campinho & M. Galay-Burgos & N. Silva & R. A. Costa & R. N. Alves & G. E. Sweeney & D. M. Power, "Molecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expression" in Cell Tissue Res (2012) 350:333–346.por
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-012-1473-x
dc.identifier.issn0302-766X
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5442
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringer Verlagpor
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs00441-012-1473-xpor
dc.subjectThyroid hormonespor
dc.subjectMetamorphosispor
dc.subjectSkinpor
dc.subjectMusclepor
dc.subjectFlatfishpor
dc.subjectAtlantic halibut Hippoglossus hippoglossus (Teleostei)por
dc.titleMolecular and cellular changes in skin and muscle during metamorphosis of Atlantic halibut (Hippoglossus hippoglossus) are accompanied by changes in deiodinases expressionpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage346por
oaire.citation.issue2
oaire.citation.startPage333por
oaire.citation.titleCell and Tissue Researchpor
oaire.citation.volume350por
person.familyNameCampinho
person.familyNameSilva
person.familyNamePower
person.givenNameMarco António
person.givenNameNádia
person.givenNameDeborah Mary
person.identifier.ciencia-id0E18-2560-6EC1
person.identifier.ciencia-id5D1F-6F3A-A1C2
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0001-9881-4421
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
person.identifier.scopus-author-id8938999600
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationf8e8c466-6a6f-4ccf-b96d-34565fe53b6c
relation.isAuthorOfPublicationa467188c-1363-4f77-a9a9-8297de10a01a
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryf8e8c466-6a6f-4ccf-b96d-34565fe53b6c

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